Nanodrug delivery: is the enhanced permeability and retention effect sufficient for curing cancer?
Nanotechnology offers several attractive design features that have prompted its exploration
for cancer diagnosis and treatment. Nanosized drugs have a large loading capacity, the …
for cancer diagnosis and treatment. Nanosized drugs have a large loading capacity, the …
Improving conventional enhanced permeability and retention (EPR) effects; what is the appropriate target?
H Kobayashi, R Watanabe, PL Choyke - Theranostics, 2013 - pmc.ncbi.nlm.nih.gov
Nano-sized therapeutic agents have several advantages over low molecular weight agents
such as a larger loading capacity, the ability to protect the payload until delivery, more …
such as a larger loading capacity, the ability to protect the payload until delivery, more …
Revisiting photodynamic therapy dosimetry: reductionist & surrogate approaches to facilitate clinical success
Photodynamic therapy (PDT) can be a highly complex treatment, with many parameters
influencing treatment efficacy. The extent to which dosimetry is used to monitor and …
influencing treatment efficacy. The extent to which dosimetry is used to monitor and …
Explicit dosimetry for photodynamic therapy: macroscopic singlet oxygen modeling
Abstract Singlet oxygen (1O2) is the major cytotoxic agent responsible for cell killing for type‐
II photodynamic therapy (PDT). An empirical four‐parameter macroscopic model is …
II photodynamic therapy (PDT). An empirical four‐parameter macroscopic model is …
Cancer drug delivery: considerations in the rational design of nanosized bioconjugates
H Kobayashi, B Turkbey, R Watanabe… - Bioconjugate …, 2014 - ACS Publications
In order to efficiently deliver anticancer agents to tumors, biocompatible nanoparticles or
bioconjugates, including antibody–drug conjugates (ADCs), have recently been designed …
bioconjugates, including antibody–drug conjugates (ADCs), have recently been designed …
A dynamic model for ALA-PDT of skin: simulation of temporal and spatial distributions of ground-state oxygen, photosensitizer and singlet oxygen
B Liu, TJ Farrell, MS Patterson - Physics in Medicine & Biology, 2010 - iopscience.iop.org
Singlet oxygen direct dosimetry and photosensitizer fluorescence photobleaching are being
investigated and applied as dosimetric tools during 5-aminolevulinic acid (ALA)-induced …
investigated and applied as dosimetric tools during 5-aminolevulinic acid (ALA)-induced …
Photosensitizer fluorescence and singlet oxygen luminescence as dosimetric predictors of topical 5-aminolevulinic acid photodynamic therapy induced clinical …
The need for patient-specific photodynamic therapy (PDT) in dermatologic and oncologic
applications has triggered several studies that explore the utility of surrogate parameters as …
applications has triggered several studies that explore the utility of surrogate parameters as …
Monte Carlo modeling of in vivo protoporphyrin IX fluorescence and singlet oxygen production during photodynamic therapy for patients presenting with superficial …
RM Valentine, CTA Brown, H Moseley… - Journal of …, 2011 - spiedigitallibrary.org
We present protoporphyrin IX (PpIX) fluorescence measurements acquired from patients
presenting with superficial basal cell carcinoma during photodynamic therapy (PDT) …
presenting with superficial basal cell carcinoma during photodynamic therapy (PDT) …
Real-time, in vivo measurement of tissular through the delayed fluorescence of endogenous protoporphyrin IX during photodynamic therapy
F Piffaretti, AM Novello, RS Kumar… - … of biomedical optics, 2012 - spiedigitallibrary.org
Tissular oxygen concentration plays a key role during photodynamic therapy (PDT).
Therefore, monitoring its local oxygen partial pressure (pO 2) may help predict and/or control …
Therefore, monitoring its local oxygen partial pressure (pO 2) may help predict and/or control …
Increasing the efficiency of photodynamic therapy by improved light delivery and oxygen supply using an anticoagulant in a solid tumor model
L Yang, Y Wei, D Xing, Q Chen - Lasers in surgery and …, 2010 - Wiley Online Library
Abstract Background and Objective The main factors in photodynamic therapy (PDT) are:
photosensitizer retention, photon absorption, and oxygen supply. Each factor has its unique …
photosensitizer retention, photon absorption, and oxygen supply. Each factor has its unique …