N‐acetylcysteine: a review of clinical usefulness (an old drug with new tricks)

GK Schwalfenberg - Journal of nutrition and metabolism, 2021 - Wiley Online Library
Objective. To review the clinical usefulness of N‐acetylcysteine (NAC) as treatment or
adjunctive therapy in a number of medical conditions. Use in Tylenol overdose, cystic …

Anti-obesity effects of metformin: a scoping review evaluating the feasibility of brown adipose tissue as a therapeutic target

K Ziqubu, SE Mazibuko-Mbeje, SXH Mthembu… - International Journal of …, 2023 - mdpi.com
Brown adipose tissue (BAT) is increasingly recognized as the major therapeutic target to
promote energy expenditure and ameliorate diverse metabolic complications. There is a …

Drug‐induced liver injury: clinical evidence of N‐acetyl cysteine protective effects

Y Ntamo, K Ziqubu, N Chellan… - Oxidative medicine …, 2021 - Wiley Online Library
Oxidative stress is a key pathological feature implicated in both acute and chronic liver
diseases, including drug‐induced liver injury (DILI). The latter describes hepatic injury …

N-acetylcysteine (NAC) and Its Role in Clinical Practice Management of Cystic Fibrosis (CF): A Review

M Guerini, G Condrò, V Friuli, L Maggi, P Perugini - Pharmaceuticals, 2022 - mdpi.com
N-acetylcysteine is the acetylated form of the amino acid L-cysteine and a precursor to
glutathione (GSH). It has been known for a long time as a powerful antioxidant and as an …

N-acetyl cysteine targets hepatic lipid accumulation to curb oxidative stress and inflammation in NAFLD: a comprehensive analysis of the literature

PV Dludla, BB Nkambule, SE Mazibuko-Mbeje… - Antioxidants, 2020 - mdpi.com
Impaired adipose tissue function and insulin resistance remain instrumental in promoting
hepatic lipid accumulation in conditions of metabolic syndrome. In fact, enhanced lipid …

[HTML][HTML] Oxidative stress in polycystic ovarian syndrome and the effect of antioxidant N-acetylcysteine on ovulation and pregnancy rate

JK Sandhu, A Waqar, A Jain, C Joseph, K Srivastava… - Cureus, 2021 - ncbi.nlm.nih.gov
Polycystic ovarian syndrome (PCOS) is an endocrinological condition that leads to infertility
in many females. N-acetylcysteine (NAC), a novel antioxidant, is being used as an adjuvant …

Coenzyme Q10 Supplementation Improves Adipokine Levels and Alleviates Inflammation and Lipid Peroxidation in Conditions of Metabolic Syndrome: A Meta …

PV Dludla, P Orlando, S Silvestri… - International journal of …, 2020 - mdpi.com
Evidence from randomized controlled trials (RCTs) suggests that coenzyme Q10 (CoQ10)
can regulate adipokine levels to impact inflammation and oxidative stress in conditions of …

Role of flavonoids in controlling obesity: molecular targets and mechanisms

A Mahboob, SM Samuel, A Mohamed, MY Wani… - Frontiers in …, 2023 - frontiersin.org
Obesity presents a major health challenge that increases the risk of several non-
communicable illnesses, such as but not limited to diabetes, hypertension, cardiovascular …

The impact of coenzyme Q10 on metabolic and cardiovascular disease profiles in diabetic patients: A systematic review and meta‐analysis of randomized controlled …

PV Dludla, TM Nyambuya, P Orlando… - Endocrinology …, 2020 - Wiley Online Library
Abstract Aims Coenzyme Q10 (CoQ10) is well known for its beneficial effects in
cardiovascular disease (CVD); however, reported evidence has not been precisely …

Obesity-induced astrocyte dysfunction impairs heterosynaptic plasticity in the orbitofrontal cortex

BK Lau, C Murphy-Royal, M Kaur, M Qiao, JS Bains… - Cell reports, 2021 - cell.com
Overconsumption of highly palatable, energy-dense food is considered a key driver of the
obesity pandemic. The orbitofrontal cortex (OFC) is critical for reward valuation of gustatory …