[HTML][HTML] Targeting p53 for the treatment of cancer
MJ Duffy, NC Synnott, S O'Grady, J Crown - Seminars in cancer biology, 2022 - Elsevier
Dysfunction of the TP53 (p53) gene occurs in most if not all human malignancies. Two
principal mechanisms are responsible for this dysfunction; mutation and downregulation of …
principal mechanisms are responsible for this dysfunction; mutation and downregulation of …
The long and the short of it: the MDM4 tail so far
S Haupt, JO Mejía-Hernández… - Journal of molecular …, 2019 - academic.oup.com
The mouse double minute 4 (MDM4) is emerging from the shadow of its more famous
relative MDM2 and is starting to steal the limelight, largely due to its therapeutic possibilities …
relative MDM2 and is starting to steal the limelight, largely due to its therapeutic possibilities …
MDM2, MDMX, and p73 regulate cell-cycle progression in the absence of wild-type p53
AM Klein, L Biderman, D Tong… - Proceedings of the …, 2021 - National Acad Sciences
The p53 tumor suppressor protein, known to be critically important in several processes
including cell-cycle arrest and apoptosis, is highly regulated by multiple mechanisms, most …
including cell-cycle arrest and apoptosis, is highly regulated by multiple mechanisms, most …
[HTML][HTML] Potential impact of PI3K-AKT signaling pathway genes, KLF-14, MDM4, miRNAs 27a, miRNA-196a genetic alterations in the predisposition and progression …
Simple Summary The genomic landscape of breast cancer (BC) is complex. Previous
research studies have not extensively elucidated the correlation of genotypes and allele …
research studies have not extensively elucidated the correlation of genotypes and allele …
Mdm2: open questions
M Dobbelstein, AJ Levine - Cancer Science, 2020 - Wiley Online Library
The Mdm2 oncoprotein and its association with p53 were discovered 30 years ago, and a
cornucopia of activities and regulatory pathways have been associated with it. In this review …
cornucopia of activities and regulatory pathways have been associated with it. In this review …
[HTML][HTML] Aglianico grape seed semi-polar extract exerts anticancer effects by modulating MDM2 expression and metabolic pathways
R Cuciniello, F Di Meo, M Sulli, OC Demurtas, M Tanori… - Cells, 2023 - mdpi.com
Grapevine (Vitis vinifera L.) seeds are rich in polyphenols including proanthocyanidins,
molecules with a variety of biological effects including anticancer action. We have previously …
molecules with a variety of biological effects including anticancer action. We have previously …
[HTML][HTML] Inflammatory breast cancer: clinical implications of genomic alterations and mutational profiling
Simple Summary Inflammatory breast cancer (IBC) is an aggressive disease with high
mortality rates. Nowadays, there is no targeted treatment for this tumor type. Based on this …
mortality rates. Nowadays, there is no targeted treatment for this tumor type. Based on this …
[HTML][HTML] Targeting MDM4 as a novel therapeutic approach in prostate cancer independent of p53 status
JO Mejía-Hernández, D Raghu, F Caramia, N Clemons… - Cancers, 2022 - mdpi.com
Simple Summary Prostate cancer is the most prevalent male cancer. It poses a survival risk if
it spreads and fails treatment. In search of fresh insight into lethal prostate cancers, we …
it spreads and fails treatment. In search of fresh insight into lethal prostate cancers, we …
[HTML][HTML] Context-dependent roles of MDMX (MDM4) and MDM2 in breast cancer proliferation and circulating tumor cells
C Gao, G Xiao, A Piersigilli, J Gou, O Ogunwobi… - Breast Cancer …, 2019 - Springer
Introduction Many human breast cancers overexpress the E3 ubiquitin ligase MDM2 and its
homolog MDMX. Expression of MDM2 and MDMX occurs in estrogen receptor α-positive …
homolog MDMX. Expression of MDM2 and MDMX occurs in estrogen receptor α-positive …
[HTML][HTML] MDMX regulates transcriptional activity of p53 and FOXO proteins to stimulate proliferation of melanoma cells
RC Heijkants, AFAS Teunisse, D de Jong, K Glinkina… - Cancers, 2022 - mdpi.com
Simple Summary We have investigated the transcriptional changes occurring in uveal and
cutaneous melanoma cell lines upon depletion of MDMX (aka: MDM4). Computational …
cutaneous melanoma cell lines upon depletion of MDMX (aka: MDM4). Computational …