Dysfunction of the TP53 (p53) gene occurs in most if not all human malignancies. Two
principal mechanisms are responsible for this dysfunction; mutation and downregulation of …

The mouse double minute 4 (MDM4) is emerging from the shadow of its more famous
relative MDM2 and is starting to steal the limelight, largely due to its therapeutic possibilities …

The p53 tumor suppressor protein, known to be critically important in several processes
including cell-cycle arrest and apoptosis, is highly regulated by multiple mechanisms, most …

Simple Summary The genomic landscape of breast cancer (BC) is complex. Previous
research studies have not extensively elucidated the correlation of genotypes and allele …

The Mdm2 oncoprotein and its association with p53 were discovered 30 years ago, and a
cornucopia of activities and regulatory pathways have been associated with it. In this review …

Grapevine (Vitis vinifera L.) seeds are rich in polyphenols including proanthocyanidins,
molecules with a variety of biological effects including anticancer action. We have previously …

Simple Summary Inflammatory breast cancer (IBC) is an aggressive disease with high
mortality rates. Nowadays, there is no targeted treatment for this tumor type. Based on this …

Simple Summary Prostate cancer is the most prevalent male cancer. It poses a survival risk if
it spreads and fails treatment. In search of fresh insight into lethal prostate cancers, we …

Introduction Many human breast cancers overexpress the E3 ubiquitin ligase MDM2 and its
homolog MDMX. Expression of MDM2 and MDMX occurs in estrogen receptor α-positive …

Simple Summary We have investigated the transcriptional changes occurring in uveal and
cutaneous melanoma cell lines upon depletion of MDMX (aka: MDM4). Computational …