Lymphatic vessels in cancer

LC Dieterich, C Tacconi, L Ducoli… - Physiological …, 2022 - journals.physiology.org
The lymphatic system, composed of initial and collecting lymphatic vessels as well as lymph
nodes that are present in almost every tissue of the human body, acts as an essential …

Vascular endothelial growth factor signaling in development and disease

S Karaman, VM Leppänen, K Alitalo - Development, 2018 - journals.biologists.com
Vascular endothelial growth factors (VEGFs) are best known for their involvement in
orchestrating the development and maintenance of the blood and lymphatic vascular …

Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments

M Janiszewska, DP Tabassum, Z Castaño… - Nature cell …, 2019 - nature.com
Most human tumours are heterogeneous, composed of cellular clones with different
properties present at variable frequencies. Highly heterogeneous tumours have poor clinical …

[HTML][HTML] How to plumb a pisces: understanding vascular development and disease using zebrafish embryos

BM Hogan, S Schulte-Merker - Developmental cell, 2017 - cell.com
Our vasculature plays diverse and critical roles in homeostasis and disease. In recent
decades, the use of zebrafish has driven our understanding of vascular development into …

Developmental toxicity of prometryn induces mitochondrial dysfunction, oxidative stress, and failure of organogenesis in zebrafish (Danio rerio)

N Min, H Park, T Hong, G An, G Song, W Lim - Journal of hazardous …, 2023 - Elsevier
Abstract Prometryn, 2-methylthio-4, 6-bis (isopropylamino)-1, 3, 5-triazine, is a selective
thiomethyl triazine herbicide widely used to control unwanted weeds and harmful insects by …

[HTML][HTML] Regulation of VEGFR signalling in lymphatic vascular development and disease: an update

GA Secker, NL Harvey - International journal of molecular sciences, 2021 - mdpi.com
The importance of lymphatic vessels in a myriad of human diseases is rapidly gaining
recognition; lymphatic vessel dysfunction is a feature of disorders including congenital …

MiR-182-5p inhibits colon cancer tumorigenesis, angiogenesis, and lymphangiogenesis by directly downregulating VEGF-C

S Yan, H Wang, X Chen, C Liang, W Shang, L Wang… - Cancer letters, 2020 - Elsevier
MicroRNAs (miRNAs) are gene modulators essential for biological processes. However, the
precise functions of miRNAs in growth and development of colon cancer are still elusive. To …

[HTML][HTML] Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration

D Gancz, BC Raftrey, G Perlmoter, R Marín-Juez… - Elife, 2019 - elifesciences.org
In recent years, there has been increasing interest in the role of lymphatics in organ repair
and regeneration, due to their importance in immune surveillance and fluid homeostasis …

[HTML][HTML] Lymphatic vessel: origin, heterogeneity, biological functions, and therapeutic targets

Z Hu, X Zhao, Z Wu, B Qu, M Yuan, Y Xing… - … and Targeted Therapy, 2024 - nature.com
Lymphatic vessels, comprising the secondary circulatory system in human body, play a
multifaceted role in maintaining homeostasis among various tissues and organs. They are …

[HTML][HTML] Development and aging of the lymphatic vascular system

A González-Loyola, TV Petrova - Advanced Drug Delivery Reviews, 2021 - Elsevier
The lymphatic vasculature has a pivotal role in regulating body fluid homeostasis, immune
surveillance and dietary fat absorption. The increasing number of in vitro and in vivo studies …