Objective Dementia has a multifactorial etiology, but the importance of individual health and
lifestyle related risk factors is often uncertain or based on few studies. The goal of this paper …

The brain is highly enriched in lipids, and an intensive study of these lipids may be
informative, not only of normal brain function but also of changes with age and in disease. In …

Introduction Identifying circulating metabolites that are associated with cognition and
dementia may improve our understanding of the pathogenesis of dementia and provide …

The Geroscience aims at a better understanding of the biological processes of aging, to
prevent and/or delay the onset of chronic diseases and disability as well as to reduce the …

Background The relationship between biomarkers of metabolic syndrome and insulin
resistance, plasma triglyceride/HDL cholesterol (TG/HDL-C) ratio, on the rate of cognitive …

Alzheimer's disease is the public health crisis of the 21st century. There is a clear need for a
widely available, inexpensive and reliable method to diagnosis Alzheimer's disease in the …

Glaucoma is a chronic disease that shares many similarities with other neurodegenerative
disorders of the central nervous system. This study was designed to evaluate the association …

High-density lipoproteins (HDLs) are a heterogeneous group of lipoproteins composed of
various lipids and proteins. HDL is formed both in the systemic circulation and in the brain. In …

Paragraph Whole-genome sequencing (WGS) provides a comprehensive view of the
genome, enabling detection of coding and non-coding genetic variation, and surveying …

The apolipoprotein E (ApoE) ε4 allele is the strongest risk factor of sporadic Alzheimer's
disease (AD), however, the fluid concentrations of ApoE and its different isoforms (ApoE2 …