Binuclear metallohydrolases are a structurally diverse group of enzymes that use binuclear
metal ion centers to catalyze the hydrolysis of amides and esters of carboxylic and …

DNA double-strand breaks (DSBs) can arise from internal or external sources of damage,
and the rapid detection, processing, and repair of this damage is important for cell viability …

The carboxy-terminal binding protein (CtBP)-interacting protein (CtIP) is known to function in
5′ strand resection during homologous recombination, similar to the budding yeast Sae2 …

Protein phosphorylation is a ubiquitous post-translational modification used to regulate
cellular processes and proteome architecture by modulating protein-protein interactions …

Despite their diverse functions, proteins are inherently constructed from a limited set of
building blocks. These compositional constraints pose significant challenges to protein …

The glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes is a promiscuous
binuclear metallohydrolase that catalyzes the hydrolysis of mono-, di-, and triester …

Calcineurin-like metallophosphoesterases (MPEs) form a large superfamily of binuclear
metal-ion-centre-containing enzymes that hydrolyse phosphomono-, phosphodi-or …

The structure of the glycerophosphodiesterase (GDPD) from Enterobacter aerogenes,
GpdQ, has been solved by SAD phasing from the active site metal ions. Structural analysis …

The glycerophosphodiesterase from Enterobacter aerogenes (GpdQ) belongs to the family
of binuclear metallohydrolases and has attracted recent attention due to its potential in …

Binuclear metallophosphoesterases are an enzyme superfamily defined by a shared fold
and a conserved active site. Although many family members have been characterized …