[HTML][HTML] Systemic therapies for salivary gland adenoid cystic carcinoma
Adenoid cystic carcinoma (ACC) is a slow growing, but relentless cancer. Due to its rarity
and lack of understanding of its molecular etiology, no standard chemotherapy for ACC …
and lack of understanding of its molecular etiology, no standard chemotherapy for ACC …
[HTML][HTML] MYB-NFIB fusion transcript in adenoid cystic carcinoma: Current state of knowledge and future directions
Adenoid cystic carcinoma (ACC) is the most common type of salivary gland cancer that can
also arise in other primary sites. Regardless of the site, most ACC cases carry a recurrent …
also arise in other primary sites. Regardless of the site, most ACC cases carry a recurrent …
NK cells shape pancreatic and oral tumor microenvironments; role in inhibition of tumor growth and metastasis
We have recently shown that natural killer (NK) cells select and differentiate cancer stem
cells (CSCs)/undifferentiated tumors via secreted and membrane bound IFN-gamma (IFN-γ) …
cells (CSCs)/undifferentiated tumors via secreted and membrane bound IFN-gamma (IFN-γ) …
An organoid library of salivary gland tumors reveals subtype-specific characteristics and biomarkers
B Wang, J Gan, Z Liu, Z Hui, J Wei, X Gu, Y Mu… - Journal of Experimental …, 2022 - Springer
Abstract Background Salivary gland tumors (SGTs) include a large group of rare neoplasms
in the head and neck region, and the heterogeneous and overlapping features among the …
in the head and neck region, and the heterogeneous and overlapping features among the …
p53 inhibits Bmi-1-driven self-renewal and defines salivary gland cancer stemness
C Rodriguez-Ramirez, Z Zhang, KA Warner… - Clinical Cancer …, 2022 - AACR
Purpose: Mucoepidermoid carcinoma (MEC) is a poorly understood salivary gland
malignancy with limited therapeutic options. Cancer stem cells (CSC) are considered drivers …
malignancy with limited therapeutic options. Cancer stem cells (CSC) are considered drivers …
The concept of cancer stem cells: Elaborating on ALDH1B1 as an emerging marker of cancer progression
Cancer is a multifactorial, complex disease exhibiting extraordinary phenotypic plasticity and
diversity. One of the greatest challenges in cancer treatment is intratumoral heterogeneity …
diversity. One of the greatest challenges in cancer treatment is intratumoral heterogeneity …
Synergistic efficacy of combined EGFR and HDAC inhibitors overcomes tolerance to EGFR monotherapy in salivary mucoepidermoid carcinoma
K Parag-Sharma, J Tasoulas, AM Musicant… - Oral oncology, 2021 - Elsevier
Objectives Mucoepidermoid carcinoma (MEC) is the most common type of salivary gland
malignancy. Advanced or high-grade MECs are refractory to chemotherapy, often leading to …
malignancy. Advanced or high-grade MECs are refractory to chemotherapy, often leading to …
Therapeutic inhibition of Bmi-1 ablates chemoresistant cancer stem cells in adenoid cystic carcinoma
Abstract Objectives Adenoid Cystic Carcinomas (ACC) typically show modest response to
cytotoxic therapy. Cancer stem cells (CSC) have been implicated in chemoresistance and …
cytotoxic therapy. Cancer stem cells (CSC) have been implicated in chemoresistance and …
[HTML][HTML] Mitochondrial fission regulator 2 (MTFR2) promotes growth, migration, invasion and tumour progression in breast cancer cells
G Lu, L Yuanhui, T Wang, W Lin, J Lu, Y Ma… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
Introduction: Mitochondrial fission regulator 2 (MTFR2) belongs to the MTFR family, and 2
isoforms of MTFR2 are produced by alternative splicing. The role of MTFR2 in breast cancer …
isoforms of MTFR2 are produced by alternative splicing. The role of MTFR2 in breast cancer …
Bmi-1: A master regulator of head and neck cancer stemness
Head and neck cancers are composed of a diverse group of malignancies, many of which
exhibit an unacceptably low patient survival, high morbidity and poor treatment outcomes …
exhibit an unacceptably low patient survival, high morbidity and poor treatment outcomes …