The widespread use of molecular machines in biology has long suggested that great
rewards could come from bridging the gap between synthetic molecular systems and the …

The Ni-catalyzed reductive coupling of alkyl/aryl with other electrophiles has evolved to be
an important protocol for the construction of C–C bonds. This chapter first emphasizes the …

Cross-coupling between two similar or identical functional groups to form a new C–C bond
is a powerful tool to rapidly assemble complex molecules from readily available building …

The pervasive occurrence of saturated stereogenic carbon centers in pharmaceuticals,
agrochemicals, functional organic materials, and natural products has stimulated great …

The formation of C–C bonds directly by catalytic reductive cross-coupling of two different
electrophiles represents one of the practical synthetic protocols that differs from the …

A critical overview of the catalytic joining of two different electrophiles, cross-electrophile
coupling (XEC), is presented with an emphasis on the central challenge of cross-selectivity …

Alkyl chlorides and aryl chlorides are among the most abundant and stable carbon
electrophiles. Although their coupling with carbon nucleophiles is well developed, the cross …

The active template approach to interlocked molecules takes advantage of the ability of
metal ions to both organize precursor fragments for mechanical bond formation and to …

More than a quarter of a century after the first metal template synthesis of a [2] catenane in
Strasbourg, there now exists a plethora of strategies available for the construction of …

Cross coupling of non-activated alkyl halides is a potentially transformative methodology in
organic synthesis. Herein we review the recent development of nickel-catalyzed coupling of …