There is a real consensus that new antibiotics are urgently needed and are the best chance
for combating antibiotic resistance. The phylum Actinobacteria is one of the main producers …

Actinomycetes are prolific sources of bioactive molecules. Traditional workflows including
bacterial isolation, fermentation, metabolite identification and structure elucidation have …

Background The deep-sea-derived microbe Streptomyces koyangensis SCSIO 5802
produces neoabyssomicins A–B (1–2) and abyssomicins 2 (3) and 4 (4). Neoabyssomicin A …

Three new abyssomicin monomers designated neoabyssomicins D (1), E (2), and A2 (3)
and the two dimeric neoabyssomicins F (4) and G (5) were discovered from the marine …

Antifolates targeting folate biosynthesis within the shikimate-chorismate-folate metabolic
pathway are ideal and selective antimicrobials, since higher eukaryotes lack this pathway …

Neoabyssomicin A (1) possessing a caged 6/6/6 ring system fused with two additional 6/9
lactone rings, neoabyssomicin B (2) featuring a 12-membered macrolactone ring and its …

Microbial natural product discovery programs face two main challenges today: rapidly
prioritizing strains for discovering new molecules and avoiding the rediscovery of already …

Marine microorganisms live in dramatically different environments and have attracted much
attention for their structurally unique natural products with potential strong biological activity …

The discovery of new, safe, and effective pesticides is one of the main means for modern
crop protection and parasitic disease control. During the search for new insecticidal …

A novel 6/6/5/6 tetracyclic polyketide named chartspiroton (1) was isolated from a medicinal
plant endophytic Streptomyces in Dendrobium officinale. The complete structure assignment …