Engineering signalling pathways in mammalian cells
AV Leopold, VV Verkhusha - Nature biomedical engineering, 2024 - nature.com
In mammalian cells, signalling pathways orchestrate cellular growth, differentiation and
survival, as well as many other processes that are essential for the proper functioning of …
survival, as well as many other processes that are essential for the proper functioning of …
A sensitive red/far-red photoswitch for controllable gene therapy in mouse models of metabolic diseases
L Qiao, L Niu, M Wang, Z Wang, D Kong, G Yu… - Nature …, 2024 - nature.com
Red light optogenetic systems are in high demand for the precise control of gene expression
for gene-and cell-based therapies. Here, we report a red/far-red l ight-i nducible p …
for gene-and cell-based therapies. Here, we report a red/far-red l ight-i nducible p …
Engineering bacteriophytochrome-coupled photoactivated adenylyl cyclases for enhanced optogenetic camp modulation
Sensory photoreceptors abound in nature and enable organisms to adapt behavior,
development, and physiology to environmental light. In optogenetics, photoreceptors allow …
development, and physiology to environmental light. In optogenetics, photoreceptors allow …
Optogenetic clustering and membrane translocation of the BcLOV4 photoreceptor
AA Pal, W Benman, TR Mumford… - Proceedings of the …, 2023 - National Acad Sciences
Optogenetic tools respond to light through one of a small number of behaviors including
allosteric changes, dimerization, clustering, or membrane translocation. Here, we describe a …
allosteric changes, dimerization, clustering, or membrane translocation. Here, we describe a …
人工调控受体聚集的化学合成生物学策略及应用
袁燕燕， 陈慧芳， 杨思慧， 王洪辉， 聂舟 - 合成生物学, 2024 - synbioj.cip.com.cn
细胞表面受体的聚集和激活在多种生物过程中发挥着重要作用, 如细胞迁移, 增殖, 凋亡和分化.
鉴于受体介导的细胞功能对健康和疾病的广泛相关性, 研究人员一直致力于探究细胞受体信号 …
鉴于受体介导的细胞功能对健康和疾病的广泛相关性, 研究人员一直致力于探究细胞受体信号 …
Advanced deep-tissue imaging and manipulation enabled by biliverdin reductase knockout.
We developed near-infrared (NIR) photoacoustic and fluorescence probes, as well as
optogenetic tools from bacteriophytochromes, and enhanced their performance using …
optogenetic tools from bacteriophytochromes, and enhanced their performance using …
Engineering artificial receptor cluster: chemical synthetic biology strategies and emerging applications
Y YUAN, H CHEN, S YANG, H WANG… - Synthetic Biology …, 2024 - synbioj.cip.com.cn
Cell surface receptors are important membrane proteins that play a crucial role in mediating
signal transduction between the intra-and extracellular environments, which sense …
signal transduction between the intra-and extracellular environments, which sense …
[HTML][HTML] Development of Near-Infrared Optogenetic Tools for Applications in Neuronal and Non-Neuronal Cells
M Karasev - 2023 - helda.helsinki.fi
Optogenetics, a revolutionary technique that enables precise spatiotemporal control of
cellular activity using light-sensitive proteins, has transformed the fields of cell biology and …
cellular activity using light-sensitive proteins, has transformed the fields of cell biology and …
[HTML][HTML] The story of OptoMedicine: REDLIP system for metabolic homeostasis control
L Qiao - communities.springernature.com
The story of OptoMedicine: REDLIP system for metabolic homeostasis control | Research
Communities by Springer Nature Share your thoughts about the Research Communities in our …
Communities by Springer Nature Share your thoughts about the Research Communities in our …