Choroideremia is an X‐chromosome‐linked disease that leads to the degeneration of the
choriocapillaris, the retinal pigment epithelium and the photoreceptor layer in the eye. The …

Many genes required for cell polarity development in budding yeast have been identified
and arranged into a functional hierarchy. Core elements of the hierarchy are widely …

3-Hydroxy-3-methylglutaryl (HMG)-CoA reductase (HMGR), the rate-limiting enzymes of
sterol synthesis, undergoes feedback-regulated endoplasmic reticulum degradation in both …

Little is known about the molecular machinery that directs secretory vesicles to the site of cell
separation during cytokinesis. We show that in Saccharomyces cerevisiae, the class V …

Rab geranylgeranyl transferase is an enzyme responsible for double geranylgeranylation of
Rab proteins in all eukaryotic cells. In the present article we would like to focus on new …

Lipid anchors are common post‐translational modifications for proteins engaged in
signaling and vesicular transport in eukaryotic cells. Rab proteins are geranylgeranylated at …

Members of the family of small GTPases regulate a variety of important cellular functions. In
order to accomplish this, tight temporal and spatial regulation is absolutely necessary. The …

MAPK pathways regulate different responses yet can share common components. Although
core regulators of MAPK pathways are well known, new pathway regulators continue to be …

Rab GTPases participating in the regulation of vesicle trafficking in eukaryotes are
geranylgeranylated by the Rab geranylgeranyl transferase (RabGGTase) in complex with …

The Rab/Ypt small G proteins are essential for intracellular vesicle trafficking in mammals
and yeast. The vesicle‐docking process requires that Ypt proteins are located in the vesicle …