Objective Gastric cancer is a major gastrointestinal malignancy for which targeted therapies
are emerging as treatment options. This study sought to identify the most prevalent …

The fibroblast growth factor receptor (FGFR) cascade plays crucial roles in tumor cell
proliferation, angiogenesis, migration and survival. Accumulating evidence suggests that in …

Purpose JNJ-42756493 is an orally administered pan-fibroblast growth factor receptor
(FGFR) tyrosine kinase inhibitor. This first-in-human study evaluates the safety …

The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) signaling pathway
plays a fundamental role in many physiologic processes, including embryogenesis, adult …

The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) signaling axis plays
an important role in normal organ, vascular, and skeletal development. Deregulation of …

Lung cancer is the leading cause of cancer-related deaths worldwide. Next to
adenocarcinoma, squamous cell carcinoma (SCC) of the lung is the most frequent histologic …

Aberrant activation of FGFR has been linked to the pathogenesis of many tumor types.
Selective inhibition of FGFR has emerged as a promising approach for cancer treatment …

Activation of fibroblast growth factor receptors (FGFR) is a common oncogenic event. Little is
known about the determinants of sensitivity to FGFR inhibition and how these may vary …

Metastasis is the underlying cause of death for the majority of breast cancer patients.
Despite significant advances in recent years in basic research and clinical development …

To date therapeutic options for squamous cell lung cancer patients remain scarce because
no druggable targets have been identified so far. Aberrant signaling by FGFs (fibroblast …