ABSTRACT DNA methylation is an epigenetic modification critical to normal genome
regulation and development. The vitamin folate is a key source of the one carbon group …

Epigenetic marking systems confer stability of gene expression during mammalian
development. Genome-wide epigenetic reprogramming occurs at stages when …

Abstract In mammals, DNA 5-hydroxymethylcytosine (5hmC) is involved in methylation
reprogramming during early embryonic development. Yet, to what extent 5hmC participates …

De novo DNA methylation (DNAme) in mammalian germ cells is dependent on DNMT3A
and DNMT3L. However, oocytes and spermatozoa show distinct patterns of DNAme. In …

Sperm and eggs carry distinctive epigenetic modifications that are adjusted by
reprogramming after fertilization. The paternal genome in a zygote undergoes active DNA …

Germline stem cells that produce oocytes in vitro and fertilization-competent eggs in vivo
have been identified in and isolated from adult mouse ovaries. Here we describe and …

Cell-fate decisions remain poorly understood at the chromatin level. Here, we map
chromatin remodeling dynamics during induction of pluripotent stem cells. ATAC-seq …

Reprogramming of mouse and human somatic cells can be achieved by ectopic expression
of transcription factors, but with low efficiencies. We report that DNA methyltransferase and …

Nanog is a divergent homeodomain protein found in mammalian pluripotent cells and
developing germ cells,. Deletion of Nanog causes early embryonic lethality, whereas …

Adult germline stem cells are capable of self-renewal, tissue regeneration and production of
large numbers of differentiated progeny. We show here that the classical mouse mutant …