Effects of clinical medications on male fertility and prospects for stem cell therapy

P Mo, Z Zhao, X Ke, Y Fan, C Li - Frontiers in Cell and Developmental …, 2023 - frontiersin.org
An increasing number of men require long-term drug therapy for various diseases. However,
the effects of long-term drug therapy on male fertility are often not well evaluated in clinical …

Different effects of SSRIs, Bupropion, and Trazodone on Mitochondrial Functions and Monoamine oxidase isoform activity

M Ľupták, Z Fišar, J Hroudová - Antioxidants, 2023 - mdpi.com
Mitochondrial dysfunction is involved in the pathophysiology of psychiatric and
neurodegenerative disorders and can be used as a modulator and/or predictor of treatment …

The reprotoxic adverse side effects of neurogenic and neuroprotective drugs: current use of human organoid modeling as a potential alternative to preclinical models

MM Abady, JS Jeong, HJ Kwon, AM Assiri… - Frontiers in …, 2024 - frontiersin.org
The management of neurological disorders heavily relies on neurotherapeutic drugs, but
notable concerns exist regarding their possible negative effects on reproductive health …

Elucidating the molecular mechanisms underlying the induction of autophagy by antidepressant-like substances in C57BL/6J mouse testis model upon LPS challenge

P Sołek, E Czechowska, M Sowa-Kućma… - Cell Communication and …, 2023 - Springer
The treatment of depression with pharmaceuticals is associated with many adverse side
effects, including male fertility problems. The precise mechanisms by which these agents …

Molecular consequences of depression treatment: A potential in vitro mechanism for antidepressants-induced reprotoxic side effects

P Sołek, J Mytych, A Tabęcka-Łonczyńska… - International journal of …, 2021 - mdpi.com
The incidence of depression among humans is growing worldwide, and so is the use of
antidepressants. However, our fundamental understanding regarding the mechanisms by …

Sex-dependent differences in stress-induced depression in Wistar rats are accompanied predominantly by changes in phosphatidylcholines and sphingomyelins

A Leskanicova, M Babincak, F Mochnacky… - Journal of Physiology …, 2021 - zora.uzh.ch
With a high annual and lifetime prevalence, depression is becoming the leading contributor
to the global disease burden. During the COVID-19 crisis, the depression and mood …

[HTML][HTML] Antibiotics/coccidiostat exposure induces gut-brain axis remodeling for Akt/mTOR activation and BDNF-mediated neuroprotection in APEC-infected turkeys

P Sołek, A Stępniowska, O Koszła, J Jankowski… - Poultry Science, 2025 - Elsevier
The poultry industry relies extensively on antibiotics and coccidiostats as essential tools for
disease management and productivity enhancement. However, increasing concerns about …

The Preventive Effect of Zinc Sulfate against Olanzapine-Induced Testicular Toxicity in Male Rats

H Ebaid, SAE Bashandy, I Hassan, J Al-Tamimi… - … Trace Element Research, 2024 - Springer
Male infertility is a complex and multifactorial clinical condition affecting a large population
attributed to several factors, including perturbation in oxidative stress and the level of …

The ameliorating effect of Rutin on hepatotoxicity and inflammation induced by the daily administration of vortioxetine in rats

MM Anwar, IMI Laila - BMC Complementary Medicine and Therapies, 2024 - Springer
Background Vortioxetine (VORTX) is a potent and selective type of selective serotonin
reuptake inhibitor (SSRI) that is mainly prescribed for treating major depression along with …

[HTML][HTML] Developing rat testicular organoid models for assessing the reproductive toxicity of antidepression drugs in vitro: Testicular organoids to assess …

S Wu, X Li, P Li, T Li, G Huang, Q Sun… - Acta Biochimica et …, 2022 - ncbi.nlm.nih.gov
With the increasing incidence of depression worldwide, antidepressant medications are
commonly used in males of reproductive age for long-term treatment of depression, as well …