RNA adopts 3D structures that confer varied functional roles in human biology and
dysfunction in disease. Approaches to therapeutically target RNA structures with small …

Riboswitches are structured noncoding RNA domains used by many bacteria to monitor the
concentrations of target ligands and regulate gene expression accordingly. In the past 20 …

RNA-based therapies, including RNA molecules as drugs and RNA-targeted small
molecules, offer unique opportunities to expand the range of therapeutic targets. Various …

S-Adenosyl-l-methionine (SAM)-responsive riboswitches play a central role in the regulation
of bacterial gene expression at the level of transcription attenuation or translation inhibition …

Target occupancy is often insufficient to elicit biological activity, particularly for RNA,
compounded by the longstanding challenges surrounding the molecular recognition of RNA …

RNAs fold into 3D structures that range from simple helical elements to complex tertiary
structures and quaternary ribonucleoprotein assemblies. The functions of many regulatory …

Functional nucleic acids (FNAs), including DNA aptamers and DNAzymes, are finding
increasing use as molecular recognition elements for point-of-care (POC) assays and …

More than 55 distinct classes of riboswitches that respond to small metabolites or elemental
ions have been experimentally validated to date. The ligands sensed by these riboswitches …

This review aims at juxtaposing common versus distinct structural and functional strategies
that are applied by aptamers, riboswitches, and ribozymes/DNAzymes. Focusing on recently …

Riboswitches are commonly used by bacteria to detect a variety of metabolites and ions to
regulate gene expression. To date, nearly 40 different classes of riboswitches have been …