The ability to efficiently adapt metabolism by substrate sensing, trafficking, storage, and
utilization, dependent on availability and requirement, is known as metabolic flexibility. In …

It is well accepted that aging is an important contributing factor to the development of
osteoarthritis (OA). The mechanisms responsible appear to be multifactorial and may …

Objectives While various monocyte chemokine systems are increased in expression in
osteoarthritis (OA), the hierarchy of chemokines and chemokine receptors in mediating …

Background and aims Clinical evidence exists that patients with diabetes are at higher risk
for Coronavirus disease 2019 (COVID-19). We investigated the physiological origins of this …

Many local and systemic diseases especially diseases that are leading causes of death
globally like chronic obstructive pulmonary disease, atherosclerosis with ischemic heart …

Ageing, like obesity, is often associated with alterations in metabolic and inflammatory
processes resulting in morbidity from diseases characterised by poor metabolic control …

We propose in this review that hormesis, a concept profoundly and systematically addressed
by Mark Mattson, has to be considered a sort of comprehensive “contact point” capable of …

Aging is considered the major risk factor for cancer, one of the most important mortality
causes in the western world. Inflammaging, a state of chronic, low-level systemic …

Polyphenols, natural products present in plant-based foods, play a protective role against
several complex diseases through their antioxidant activity and by diverse molecular …

The focus of this review is on driving neuroplasticity in a positive direction using evidence-
based interventions that also have the potential to improve general health. One goal is to …