Metabolic flexibility as an adaptation to energy resources and requirements in health and disease
RL Smith, MR Soeters, RCI Wüst… - Endocrine …, 2018 - academic.oup.com
The ability to efficiently adapt metabolism by substrate sensing, trafficking, storage, and
utilization, dependent on availability and requirement, is known as metabolic flexibility. In …
utilization, dependent on availability and requirement, is known as metabolic flexibility. In …
[HTML][HTML] Aging-related inflammation in osteoarthritis
MA Greene, RF Loeser - Osteoarthritis and cartilage, 2015 - Elsevier
It is well accepted that aging is an important contributing factor to the development of
osteoarthritis (OA). The mechanisms responsible appear to be multifactorial and may …
osteoarthritis (OA). The mechanisms responsible appear to be multifactorial and may …
CCL2/CCR2, but not CCL5/CCR5, mediates monocyte recruitment, inflammation and cartilage destruction in osteoarthritis
Objectives While various monocyte chemokine systems are increased in expression in
osteoarthritis (OA), the hierarchy of chemokines and chemokine receptors in mediating …
osteoarthritis (OA), the hierarchy of chemokines and chemokine receptors in mediating …
[HTML][HTML] Glutathione: A Samsonian life-sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation
CA Labarrere, GS Kassab - Frontiers in Nutrition, 2022 - frontiersin.org
Many local and systemic diseases especially diseases that are leading causes of death
globally like chronic obstructive pulmonary disease, atherosclerosis with ischemic heart …
globally like chronic obstructive pulmonary disease, atherosclerosis with ischemic heart …
Diabetes and metabolic syndrome as risk factors for COVID-19
M Marhl, V Grubelnik, M Magdič, R Markovič - Diabetes & Metabolic …, 2020 - Elsevier
Background and aims Clinical evidence exists that patients with diabetes are at higher risk
for Coronavirus disease 2019 (COVID-19). We investigated the physiological origins of this …
for Coronavirus disease 2019 (COVID-19). We investigated the physiological origins of this …
Deciphering the decline of metabolic elasticity in aging and obesity
Organisms must adapt to fluctuating nutrient availability to maintain energy homeostasis.
Here, we term the capacity for such adaptation and restoration" metabolic elasticity" and …
Here, we term the capacity for such adaptation and restoration" metabolic elasticity" and …
Inflammaging, hormesis and the rationale for anti-aging strategies
We propose in this review that hormesis, a concept profoundly and systematically addressed
by Mark Mattson, has to be considered a sort of comprehensive “contact point” capable of …
by Mark Mattson, has to be considered a sort of comprehensive “contact point” capable of …
[HTML][HTML] Parallels in immunometabolic adipose tissue dysfunction with ageing and obesity
Ageing, like obesity, is often associated with alterations in metabolic and inflammatory
processes resulting in morbidity from diseases characterised by poor metabolic control …
processes resulting in morbidity from diseases characterised by poor metabolic control …
Inflammaging and cancer: a challenge for the Mediterranean diet
R Ostan, C Lanzarini, E Pini, M Scurti, D Vianello… - nutrients, 2015 - mdpi.com
Aging is considered the major risk factor for cancer, one of the most important mortality
causes in the western world. Inflammaging, a state of chronic, low-level systemic …
causes in the western world. Inflammaging, a state of chronic, low-level systemic …
Network medicine framework shows that proximity of polyphenol targets and disease proteins predicts therapeutic effects of polyphenols
Polyphenols, natural products present in plant-based foods, play a protective role against
several complex diseases through their antioxidant activity and by diverse molecular …
several complex diseases through their antioxidant activity and by diverse molecular …