Overcoming the blood–brain barrier for the therapy of malignant brain tumor: current status and prospects of drug delivery approaches

K Mitusova, OO Peltek, TE Karpov… - Journal of …, 2022 - Springer
Besides the broad development of nanotechnological approaches for cancer diagnosis and
therapy, currently, there is no significant progress in the treatment of different types of brain …

Non-ionic surfactants for stabilization of polymeric nanoparticles for biomedical uses

H Cortés, H Hernández-Parra, SA Bernal-Chávez… - Materials, 2021 - mdpi.com
Surfactants are essential in the manufacture of polymeric nanoparticles by emulsion
formation methods and to preserve the stability of carriers in liquid media. The deposition of …

Small interfering RNA (siRNA) to target genes and molecular pathways in glioblastoma therapy: Current status with an emphasis on delivery systems

S Mirzaei, MK Mahabady, A Zabolian, A Abbaspour… - Life Sciences, 2021 - Elsevier
Glioblastoma multiforme (GBM) is one of the worst brain tumors arising from glial cells,
causing many deaths annually. Surgery, chemotherapy, radiotherapy and immunotherapy …

Polymeric nanoparticles—Tools in a drug delivery system in selected cancer therapies

M Madej, N Kurowska, B Strzalka-Mrozik - Applied Sciences, 2022 - mdpi.com
The increase in cancer cases is undoubtedly affecting the development of new therapeutic
approaches. Polymeric nanoparticles are of great interest. Due to their relatively small size …

[HTML][HTML] Biodegradable gellan gum hydrogels loaded with paclitaxel for HER2+ breast cancer local therapy

C Nieto, MA Vega, V Rodríguez, P Pérez-Esteban… - Carbohydrate …, 2022 - Elsevier
Hydrogels loaded with chemotherapeutics are promising tools for local tumor treatment. In
this work, redox-responsive implantable hydrogels based on gellan gum were prepared as …

Emerging strategies to fabricate polymeric nanocarriers for enhanced drug delivery across blood-brain barrier: An overview

YH Song, R De, KT Lee - Advances in Colloid and Interface Science, 2023 - Elsevier
Blood-brain barrier (BBB) serves as an essential interface between central nervous system
(CNS) and its periphery, allowing selective permeation of ions, gaseous molecules, and …

Polymeric nanoparticles for drug delivery in glioblastoma: State of the art and future perspectives

F Madani, SS Esnaashari, TJ Webster… - Journal of Controlled …, 2022 - Elsevier
Glioblastoma (GBM) is an aggressive, fatal and malignant primary brain tumor. Despite the
current standard treatment for glioblastoma patients including neurosurgical resection …

Nose to Brain Delivery of Transferrin conjugated PLGA nanoparticles for clonidine

S Sharma, A Tyagi, S Dang - International Journal of Biological …, 2023 - Elsevier
The present work focuses on the development of surface modified transferrin PLGA
nanoparticles loaded with clonidine for nose to brain delivery. The CLD-Tf-PLGA-NPs were …

Improving temozolomide biopharmaceutical properties in glioblastoma multiforme (GBM) treatment using GBM-targeting nanocarriers

LD Di Filippo, JH Azambuja, JAP Dutra, MT Luiz… - European Journal of …, 2021 - Elsevier
Glioblastoma multiforme (GBM) is the most common primary brain cancer. GBM has
aggressive development, and the pharmacological treatment remains a challenge due to …

Biosynthesis of iron nanoparticles using brown algae Spatoglossum asperum and its antioxidant and anticancer activities through in vitro and in silico studies

T Palaniyandi, G Baskar, BV… - Particulate Science …, 2023 - Taylor & Francis
Green synthesized metal nanoparticles play a significant role in biomedical applications.
This investigation focused on eco-friendly synthesized iron nanoparticles using marine …