Causes of mortality from COVID‐19 include respiratory failure, heart failure, and
sepsis/multiorgan failure. TLR4 is an innate immune receptor on the cell surface that …

Interferons (IFNs) are antiviral cytokines that play a key role in the innate immune response
to viral infections. In response to viral stimuli, cells produce and release interferons, which …

Inflammatory gene expression following genotoxic cancer therapy is well documented, yet
the events underlying its induction remain poorly understood. Inflammatory cytokines modify …

Detailed knowledge of the molecular biology of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection is crucial for understanding of viral replication, host …

Abstract Interferon regulatory factor 3 (IRF3) and type I interferons (IFNs) protect against
infections and cancer, but excessive IRF3 activation and type I IFN production cause …

Summary Interleukin-1 beta (IL-1β) is a pleiotropic mediator of inflammation and is produced
in response to a wide range of stimuli. During infection, IL-1β production occurs in parallel …

Purpose Radiation therapy (RT) is one of the main treatments for patients with unresectable
hepatocellular carcinoma (HCC). Emerging evidence indicates that the cyclic guanosine …

Nucleic acids are powerful triggers of innate immunity and can adopt the Z-conformation, an
unusual left-handed double helix. Here, we studied the biological function (s) of Z-RNA …

Over the past few years, several groups have identified new genes that are transcriptionally
induced downstream of type I interferon (IFN) signalling and that inhibit infection by …

Abstract Systems-wide profiling of breast cancer has almost always entailed RNA and DNA
analysis by microarray and sequencing techniques. Marked developments in proteomic …