Cancer stem cells in hepatocellular carcinoma—from origin to clinical implications

TKW Lee, XY Guan, S Ma - Nature reviews Gastroenterology & …, 2022 - nature.com
Hepatocellular carcinoma (HCC) is an aggressive disease with a poor clinical outcome. The
cancer stem cell (CSC) model states that tumour growth is powered by a subset of tumour …

A review of nanotechnology-based approaches for breast cancer and triple-negative breast cancer

V Jain, H Kumar, HV Anod, P Chand, NV Gupta… - Journal of Controlled …, 2020 - Elsevier
Breast cancer (BC) is one of the most prevalent cancers in women. Triple-negative breast
cancer (TNBC) in which the three major receptors ie estrogen receptor (ER), progesterone …

Cancer stem cell functions in hepatocellular carcinoma and comprehensive therapeutic strategies

YC Liu, CT Yeh, KH Lin - Cells, 2020 - mdpi.com
Hepatocellular carcinoma (HCC) is a significant cause of cancer-related mortality owing to
resistance to traditional treatments and tumor recurrence after therapy, which leads to poor …

mcPGK1-dependent mitochondrial import of PGK1 promotes metabolic reprogramming and self-renewal of liver TICs

Z Chen, Q He, T Lu, J Wu, G Shi, L He, H Zong… - Nature …, 2023 - nature.com
Liver tumour-initiating cells (TICs) contribute to tumour initiation, metastasis, progression
and drug resistance. Metabolic reprogramming is a cancer hallmark and plays vital roles in …

IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3

P Zhu, X Zhu, J Wu, L He, T Lu, Y Wang, B Liu… - Nature …, 2019 - nature.com
Intestinal stem cells (ISCs) are maintained by stemness signaling for precise modulation of
self-renewal and differentiation under homeostasis. However, the way in which intestinal …

Mettl14 inhibits bladder TIC self-renewal and bladder tumorigenesis through N6-methyladenosine of Notch1

C Gu, Z Wang, N Zhou, G Li, Y Kou, Y Luo, Y Wang… - Molecular cancer, 2019 - Springer
Abstract Background N 6-methyladenosine (m 6 A) emerges as one of the most important
modification of RNA. Bladder cancer is a common cancer type in developed countries, and …

LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells

P Zhu, Y Wang, J Wu, G Huang, B Liu, B Ye… - Nature …, 2016 - nature.com
Liver cancer stem cells (CSCs) may contribute to the high rate of recurrence and
heterogeneity of hepatocellular carcinoma (HCC). However, the biology of hepatic CSCs …

The evolving concept of liver cancer stem cells

K Nio, T Yamashita, S Kaneko - Molecular cancer, 2017 - Springer
Liver cancer is an often fatal malignant tumor with a high recurrence rate and
chemoresistance. The major malignant phenotypes of cancer, including recurrence …

lnc-β-Catm elicits EZH2-dependent β-catenin stabilization and sustains liver CSC self-renewal

P Zhu, Y Wang, G Huang, B Ye, B Liu, J Wu… - Nature structural & …, 2016 - nature.com
Liver cancer stem cells (CSCs) may contribute to the high rate of recurrence and
heterogeneity of hepatocellular carcinoma (HCC); however, the molecular mechanisms …

5-hydroxytryptamine produced by enteric serotonergic neurons initiates colorectal cancer stem cell self-renewal and tumorigenesis

P Zhu, T Lu, Z Chen, B Liu, D Fan, C Li, J Wu, L He… - Neuron, 2022 - cell.com
Colorectal cancer stem cells (CSCs) contribute to colorectal tumorigenesis and metastasis.
Colorectal CSCs reside within specialized niches and harbor self-renewal and …