The multifaceted regulation of mitochondrial dynamics during mitosis

E Pangou, I Sumara - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
Mitosis ensures genome integrity by mediating precise segregation of the duplicated genetic
material. Segregation of subcellular organelles during mitosis also needs to be tightly …

Development of MPS1 inhibitors: recent advances and perspectives

Y Zeng, X Ren, P Jin, Y Zhang, M Zhuo… - Journal of Medicinal …, 2023 - ACS Publications
Monopolar spindle kinase 1 (MPS1) plays a pivotal role as a dual-specificity kinase
governing spindle assembly checkpoint activation and sister chromatid separation in …

[HTML][HTML] VDAC1 at the crossroads of cell metabolism, apoptosis and cell stress

V Shoshan-Barmatz, EN Maldonado, Y Krelin - Cell stress, 2017 - ncbi.nlm.nih.gov
This review presents current knowledge related to VDAC1 as a multi-functional
mitochondrial protein acting on both sides of the coin, regulating cell life and death, and …

Evaluation of cell viability with a single fluorescent probe based on two kinds of fluorescence signal modes

Y Lai, T Zhang, W Song, Z Li, W Lin - Analytical Chemistry, 2021 - ACS Publications
Accurate evaluation of cell viability is important for dosage tests of anticancer drugs,
pathology, and numerous biological experiments. However, due to the serious insufficieny of …

Glutathionylation of a glycolytic enzyme promotes cell death and vigor loss during aging of elm seeds

Y Li, Y Wang, YQ He, TT Ye, X Huang, H Wu… - Plant …, 2024 - academic.oup.com
Seed deterioration during storage is a major problem in agricultural and forestry production
and for germplasm conservation. Our previous studies have shown that a mitochondrial …

Water-soluble single molecular probe for simultaneous detection of viscosity and hydrazine

Y Jin, R Sun, G Li, M Yuan, W Shao, M Cao… - … Acta Part A: Molecular …, 2023 - Elsevier
Abstract Hydrazine (N 2 H 4) can cause serious damage to human health, while intracellular
viscosity is highly associated with many diseases and cellular dysfunctions. Herein, we …

Antagonistic activities of CDC14B and CDK1 on USP9X regulate WT1-dependent mitotic transcription and survival

M Dietachmayr, A Rathakrishnan, O Karpiuk… - Nature …, 2020 - nature.com
Regulation of mitosis secures cellular integrity and its failure critically contributes to the
development, maintenance, and treatment resistance of cancer. In yeast, the dual …

Development of the first covalent monopolar spindle kinase 1 (MPS1/TTK) Inhibitor

RA M. Serafim, A da Silva Santiago… - Journal of Medicinal …, 2022 - ACS Publications
Monopolar spindle kinase 1 (MPS1/TTK) is a key element of the mitotic checkpoint and
clinically evaluated as a target in the treatment of aggressive tumors such as triple-negative …

Inhibition of mitotic kinase Mps1 promotes cell death in neuroblastoma

S Simon Serrano, W Sime, Y Abassi, R Daams… - Scientific Reports, 2020 - nature.com
Neuroblastoma is the most common paediatric cancer type. Patients diagnosed with high-
risk neuroblastoma have poor prognosis and occasionally tumours relapse. As a result …

[HTML][HTML] Exploring the Therapeutic Implications of Co-Targeting the EGFR and Spindle Assembly Checkpoint Pathways in Oral Cancer

M Calheiros-Lobo, JPN Silva, B Pinto, L Monteiro… - Pharmaceutics, 2024 - mdpi.com
Head and neck cancer (HNC), the sixth most common cancer worldwide, is increasing in
incidence, with oral squamous cell carcinoma (OSCC) as the predominant subtype. OSCC …