QTc prolongation, torsades de pointes, and psychotropic medications
Background Prolongation of the corrected QT (QTc) interval is a key issue for patients who
receive psychotropic medications. Such patients may have baseline clinical risk factors for …
receive psychotropic medications. Such patients may have baseline clinical risk factors for …
[HTML][HTML] QTc prolongation by psychotropic drugs and the risk of Torsade de Pointes
K Wenzel-Seifert, M Wittmann… - Deutsches Ärzteblatt …, 2011 - ncbi.nlm.nih.gov
Method We searched PubMed for pertinent literature on the risk of QTc prolongation and/or
TdP associated with commonly used psychotropic drugs. Results Thioridazine and …
TdP associated with commonly used psychotropic drugs. Results Thioridazine and …
The science and practice of lithium therapy
GS Malhi, M Tanious, P Das… - Australian & New …, 2012 - journals.sagepub.com
Introduction: Despite more that 60 years of clinical experience, the effective use of lithium for
the treatment of mood disorder, in particular bipolarity, is in danger of becoming obsolete. In …
the treatment of mood disorder, in particular bipolarity, is in danger of becoming obsolete. In …
QT alterations in psychopharmacology: proven candidates and suspects
PA Alvarez, J Pahissa - Current drug safety, 2010 - ingentaconnect.com
Psychotropics are among the most common causes of drug induced acquired long QT
syndrome. Blockage of Human ether-ago-go-related gene (HERG) potassium channel by …
syndrome. Blockage of Human ether-ago-go-related gene (HERG) potassium channel by …
[HTML][HTML] Lithium use in special populations
E Mohandas, V Rajmohan - Indian journal of psychiatry, 2007 - journals.lww.com
Lithium, a monovalent cation, was first used for the treatment of mania in the 1940s. Half a
century into its use, the drug continues to be the preeminent choice for bipolar disorder with …
century into its use, the drug continues to be the preeminent choice for bipolar disorder with …
Clinical use of antidepressant therapy and associated cardiovascular risk
WS Waring - Drug, healthcare and patient safety, 2012 - Taylor & Francis
A number of different psychotropic agents have been associated with an increased risk of
cardiovascular disease, and these relationships have been difficult to interpret due to the …
cardiovascular disease, and these relationships have been difficult to interpret due to the …
Hospitalized lithium overdose cases reported to theCalifornia Poison Control System
SR Offerman, JA Alsop, J Lee, JF Holmes - Clinical Toxicology, 2010 - Taylor & Francis
Background. Lithium overdose primarily results in neurologic toxicity; however, cardiac
effects have also been reported. Our aim was to describe a large cohort of hospitalized …
effects have also been reported. Our aim was to describe a large cohort of hospitalized …
Risk factors for QT prolongation associated with acute psychotropic drug overdose
N Miura, T Saito, T Taira, R Umebachi… - The American journal of …, 2015 - Elsevier
Abstract Background Antipsychotic/Antidepressant use is a risk factor for QT interval (QT)
prolongation and sudden cardiac death. However, it is unclear which drugs are risk factors …
prolongation and sudden cardiac death. However, it is unclear which drugs are risk factors …
Toxicity of lithium on isolated heart mitochondria and cardiomyocyte: A justification for its cardiotoxic adverse effect
A Salimi, E Gholamifar, P Naserzadeh… - … of biochemical and …, 2017 - Wiley Online Library
Mitochondria play an important role in myocardial tissue homeostasis; therefore,
deterioration in mitochondrial function will eventually lead to cardiomyocyte and endothelial …
deterioration in mitochondrial function will eventually lead to cardiomyocyte and endothelial …
[HTML][HTML] Effects of Toxic Lithium Levels on ECG—Findings from the LiSIE Retrospective Cohort Study
P Truedson, M Ott, K Lindmark, M Ström… - Journal of Clinical …, 2022 - mdpi.com
(1) Background: Few studies have explored the impact of lithium intoxication on the heart.(2)
Methods: We examined electrocardiogram (ECG) changes associated with lithium …
Methods: We examined electrocardiogram (ECG) changes associated with lithium …