While long non-coding RNA (lncRNA) genes have attracted a lot of attention in the last
decade, the focus regarding their mechanisms of action has been primarily on the RNA …

In eukaryotic organisms, noncoding RNAs (ncRNAs) have been implicated as important
regulators of multifaceted biological processes, including transcriptional, posttranscriptional …

The tumorigenic mechanism for pancreatic ductal adenocarcinoma (PDAC) is not clear,
although chronic inflammation is implicated. Here, we identified an inflammatory cytokine …

Hypoxia induces massive changes in alternative splicing (AS) to adapt cells to the lack of
oxygen. Here, we identify the splicing factor SRSF6 as a key factor in the AS response to …

Members of the arginine–serine-rich protein family (SR proteins) are multifunctional RNA-
binding proteins that have emerged as key determinants for mRNP formation, identity and …

SRSF7 is an essential RNA-binding protein whose misexpression promotes cancer. Here,
we describe how SRSF7 maintains its protein homeostasis in murine P19 cells using an …

Long non-coding (lnc) RNAs have emerged as critical regulators of gene expression and
are involved in almost every cellular process. They can bind to other molecules including …

Interactions between the splicing machinery and RNA polymerase II increase protein-coding
gene transcription. Similarly, exons and splicing signals of enhancer-generated long …

The RNA isoform repertoire is regulated by splicing factor (SF) expression, and alterations in
SF levels are associated with disease. SFs contain ultraconserved poison exon (PE) …

Serine/arginine-rich splicing factors (SRSFs) refer to twelve RNA-binding proteins which
regulate splice site recognition and spliceosome assembly during precursor messenger …