A major challenge in treating cancer is posed by intratumor heterogeneity, with different sub-
populations of cancer cells within the same tumor exhibiting therapy resistance through …

Despite complete resection, cancer recurrence frequently occurs in clinical practice. This
indicates that cancer cells had already metastasized from their organ of origin at the time of …

Tumors and tumor-derived cell lines contain polyploid giant cells with significantly elevated
genomic content, often with multiple nuclei. The frequency of giant cells can increase …

Great efforts have been made in revealing the mechanisms governing cancer resistance
and recurrence. The in-situ effects of cell death, caused by hypoxia and metabolic stress …

The quiescent/slow‐cycling state preserves the self‐renewal capacity of cancer stem cells
(CSCs) and leads to the therapy resistance of CSCs. The mechanisms maintaining CSCs …

Tumor repopulation occurs when residual tumor cells surviving therapies tenaciously
proliferate and re‐establish the tumor. The cellular and molecular mechanisms underlying …

Simple Summary In recent years, immunotherapy has shown great advancement, becoming
a powerful tool to combat cancer. In this context, the use of biologically derived vesicles has …

Background Gastric cancer (GC) is a major health issue in the Western world. Current
clinical imperatives for this disease include the identification of more effective biomarkers to …

Our genomes are subject to potentially deleterious alterations resulting from endogenous
sources (eg, cellular metabolism, routine errors in DNA replication and recombination) …

Metastasis is one of the predisposing factors for cancer-related mortalities worldwide.
Patients with advanced cancers (stage IV) receive palliative care with minimal possibility of …