Fibronectin in cancer: friend or foe

TC Lin, CH Yang, LH Cheng, WT Chang, YR Lin… - Cells, 2019 - mdpi.com
The role of fibronectin (FN) in tumorigenesis and malignant progression has been highly
controversial. Cancerous FN plays a tumor-suppressive role, whereas it is pro-metastatic …

Angiopoietin-like proteins in angiogenesis, inflammation and cancer

C Carbone, G Piro, V Merz, F Simionato… - International journal of …, 2018 - mdpi.com
Altered expression of secreted factors by tumor cells or cells of the tumor microenvironment
is a key event in cancer development and progression. In the last decade, emerging …

A novel anoikis-related gene signature predicts prognosis in patients with head and neck squamous cell carcinoma and reveals immune infiltration

H Chi, P Jiang, K Xu, Y Zhao, B Song, G Peng… - Frontiers in …, 2022 - frontiersin.org
Background: Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive
disease with a poor prognosis for advanced tumors. Anoikis play a key role in cancer …

Exosomal protein angiopoietin-like 4 mediated radioresistance of lung cancer by inhibiting ferroptosis under hypoxic microenvironment

Y Zhang, X Liu, L Zeng, X Zhao, Q Chen, Y Pan… - British Journal of …, 2022 - nature.com
Background Hypoxia-mediated radioresistance is a major reason for the adverse
radiotherapy outcome of non-small cell lung cancer (NSCLC) in clinical, but the underlying …

Obesity and breast cancer: current insights on the role of fatty acids and lipid metabolism in promoting breast cancer growth and progression

C Blücher, SC Stadler - Frontiers in endocrinology, 2017 - frontiersin.org
Obesity and excess accumulation of adipose tissue are known risk factors for several types
of cancer, including breast cancer. With the incidence of obesity constantly rising worldwide …

Silencing HIF-1α aggravates non-alcoholic fatty liver disease in vitro through inhibiting PPAR-α/ANGPTL4 singling pathway

Y He, W Yang, L Gan, S Liu, Q Ni, Y Bi, T Han… - Gastroenterologia y …, 2021 - Elsevier
Objective Non-alcoholic fatty liver disease (NAFLD) is an aberrant lipid metabolism disease.
Hypoxia inducible factor-1 (HIF-1α) is a transcription factor which plays an important part in …

[HTML][HTML] Oleic acid-induced NOX4 is dependent on ANGPTL4 expression to promote human colorectal cancer metastasis

CJ Shen, KY Chang, BW Lin, WT Lin, CM Su… - Theranostics, 2020 - ncbi.nlm.nih.gov
Background: Colorectal cancer (CRC) progression and related mortality are highly
associated with metabolic disorders. However, the molecular mechanism involved in the …

Lipid accumulation-mediated histone hypoacetylation drives persistent NK cell dysfunction in anti-tumor immunity

D Jiao, R Sun, X Ren, Y Wang, P Tian, Y Wang… - Cell reports, 2023 - cell.com
Hyperlipidemia impairs anti-tumor immune responses and is closely associated with
increased human cancer incidence and mortality. However, the underlying mechanisms are …

Unveiling the MUFA–cancer connection: insights from endogenous and exogenous perspectives

Z Guo, KF Bergeron, M Lingrand… - International journal of …, 2023 - mdpi.com
Monounsaturated fatty acids (MUFAs) have been the subject of extensive research in the
field of cancer due to their potential role in its prevention and treatment. MUFAs can be …

Activated HGF-c-Met axis in head and neck cancer

L Arnold, J Enders, SM Thomas - Cancers, 2017 - mdpi.com
Head and neck squamous cell carcinoma (HNSCC) is a highly morbid disease. Recent
developments including Food and Drug Administration (FDA) approved molecular targeted …