Juvenile myelomonocytic leukemia (JMML) is a unique clonal hematopoietic disorder of
early childhood. It is classified as an overlap myeloproliferative/myelodysplastic neoplasm …

Multi‐omics studies promise the improved characterization of biological processes across
molecular layers. However, methods for the unsupervised integration of the resulting …

Juvenile myelomonocytic leukemia (JMML) is a rare pediatric leukemia characterized by
mutations in five canonical RAS pathway genes. The diagnosis is made by typical clinical …

Purpose: Known clinical and genetic markers have limitations in predicting disease course
and outcome in juvenile myelomonocytic leukemia (JMML). DNA methylation patterns in …

Myelodysplastic syndromes/myeloproliferative neoplasms (MDS/MPN) are aggressive
myeloid malignancies recognized as a distinct category owing to their unique combination of …

Myelodysplastic syndrome (MDS) is a clonal bone marrow disorder, typically of older adults,
which is characterized by ineffective hematopoiesis, peripheral blood cytopenias and risk of …

Simple Summary Juvenile myelomonocytic leukemia (JMML) is a rare pediatric
myelodysplastic/myeloproliferative neoplasm characterized by the constitutive activation of …

The past decade has seen rapid development in DNA methylation (DNAm) microarrays,
including the Illumina HumanMethylation27 and HumanMethylation450 (450 K) chips, which …

Juvenile myelomonocytic leukaemia (JMML) is a rare clonal disorder of early childhood.
Constitutive activation of the RAS pathway is the initial event in JMML. Around 90% of …

Juvenile myelomonocytic leukemia (JMML) is a pediatric myelodysplastic/myeloproliferative
neoplasm overlap syndrome with sustained peripheral blood monocytosis, aggressive …