Recent research advancements indicate that atopic dermatitis (AD) is a complex disease
characterized by different subtypes/phenotypes based on age, disease chronicity, ethnicity …

Objective To provide an overview of filaggrin biology and the role of filaggrin variants in
atopic dermatitis (AD) and allergic disease. Data Sources We performed a PubMed literature …

Background Atopic dermatitis is the most common chronic inflammatory skin disorder,
affecting up to 20% of children and 10% of adults in industrialized countries. This highly …

The epidermis protects human subjects from exogenous stressors and helps to maintain
internal fluid and electrolyte homeostasis. Filaggrin is a crucial epidermal protein that is …

Keratohyalin granules were discovered in the mid-19th century in cells that terminally
differentiate to form the outer, cornified layer of the epidermis. The first indications of the …

Highlights•Inherited or acquired filaggrin deficiency plays an essential role in AD.•Increasing
knowledge has been gained about consequences of filaggrin deficiency.•Novel murine and …

Skin barrier abnormalities have been suggested to play an essential role in initiation of early
atopic dermatitis (AD). Antigen penetration through a compromised barrier likely leads to …

Atopic dermatitis (AD) is a chronic inflammatory skin condition with complex etiology that is
dependent upon interactions between the host and the environment. Acute skin lesions …

Atopic dermatitis (AD) is a multifactorial inflammatory skin disease resulting from interactions
between genetic susceptibility and environmental factors. The pathogenesis of AD is poorly …

I review how diverse inherited and acquired abnormalities in epidermal structural and
enzymatic proteins converge to produce defective permeability barrier function and …