Atopic dermatitis endotypes and implications for targeted therapeutics
T Czarnowicki, H He, JG Krueger… - Journal of Allergy and …, 2019 - Elsevier
Recent research advancements indicate that atopic dermatitis (AD) is a complex disease
characterized by different subtypes/phenotypes based on age, disease chronicity, ethnicity …
characterized by different subtypes/phenotypes based on age, disease chronicity, ethnicity …
The role of filaggrin in atopic dermatitis and allergic disease
C Drislane, AD Irvine - Annals of Allergy, Asthma & Immunology, 2020 - Elsevier
Objective To provide an overview of filaggrin biology and the role of filaggrin variants in
atopic dermatitis (AD) and allergic disease. Data Sources We performed a PubMed literature …
atopic dermatitis (AD) and allergic disease. Data Sources We performed a PubMed literature …
Atopic dermatitis: the skin barrier and beyond
T Tsakok, R Woolf, CH Smith… - British Journal of …, 2019 - academic.oup.com
Background Atopic dermatitis is the most common chronic inflammatory skin disorder,
affecting up to 20% of children and 10% of adults in industrialized countries. This highly …
affecting up to 20% of children and 10% of adults in industrialized countries. This highly …
Causes of epidermal filaggrin reduction and their role in the pathogenesis of atopic dermatitis
JP Thyssen, S Kezic - Journal of Allergy and Clinical Immunology, 2014 - Elsevier
The epidermis protects human subjects from exogenous stressors and helps to maintain
internal fluid and electrolyte homeostasis. Filaggrin is a crucial epidermal protein that is …
internal fluid and electrolyte homeostasis. Filaggrin is a crucial epidermal protein that is …
The discovery and function of filaggrin
JK Hoober, LL Eggink - International Journal of Molecular Sciences, 2022 - mdpi.com
Keratohyalin granules were discovered in the mid-19th century in cells that terminally
differentiate to form the outer, cornified layer of the epidermis. The first indications of the …
differentiate to form the outer, cornified layer of the epidermis. The first indications of the …
Atopic dermatitis and filaggrin
B Cabanillas, N Novak - Current opinion in immunology, 2016 - Elsevier
Highlights•Inherited or acquired filaggrin deficiency plays an essential role in AD.•Increasing
knowledge has been gained about consequences of filaggrin deficiency.•Novel murine and …
knowledge has been gained about consequences of filaggrin deficiency.•Novel murine and …
Novel concepts of prevention and treatment of atopic dermatitis through barrier and immune manipulations with implications for the atopic march
T Czarnowicki, JG Krueger… - Journal of Allergy and …, 2017 - Elsevier
Skin barrier abnormalities have been suggested to play an essential role in initiation of early
atopic dermatitis (AD). Antigen penetration through a compromised barrier likely leads to …
atopic dermatitis (AD). Antigen penetration through a compromised barrier likely leads to …
Skin barrier defects in atopic dermatitis
R Agrawal, JA Woodfolk - Current allergy and asthma reports, 2014 - Springer
Atopic dermatitis (AD) is a chronic inflammatory skin condition with complex etiology that is
dependent upon interactions between the host and the environment. Acute skin lesions …
dependent upon interactions between the host and the environment. Acute skin lesions …
Molecular mechanisms of cutaneous inflammatory disorder: atopic dermatitis
JE Kim, JS Kim, DH Cho, HJ Park - International journal of molecular …, 2016 - mdpi.com
Atopic dermatitis (AD) is a multifactorial inflammatory skin disease resulting from interactions
between genetic susceptibility and environmental factors. The pathogenesis of AD is poorly …
between genetic susceptibility and environmental factors. The pathogenesis of AD is poorly …
Mechanisms of abnormal lamellar body secretion and the dysfunctional skin barrier in patients with atopic dermatitis
PM Elias, JS Wakefield - Journal of allergy and clinical immunology, 2014 - Elsevier
I review how diverse inherited and acquired abnormalities in epidermal structural and
enzymatic proteins converge to produce defective permeability barrier function and …
enzymatic proteins converge to produce defective permeability barrier function and …