In Silico Prediction of Pharmaceutical Degradation Pathways: A Benchmarking Study Using the Software Program Zeneth
R Hemingway, SW Baertschi, D Benstead… - … Process Research & …, 2024 - ACS Publications
Zeneth, a software application for the prediction of chemical degradation of small organic
molecules, incorporates a knowledge base of rules to predict degradation pathways. In …
molecules, incorporates a knowledge base of rules to predict degradation pathways. In …
Insights into the degradation chemistry of tazarotene, a third generation acetylenic retinoid: LC-HRMS (Orbitrap), LC-MSn and NMR characterization of its degradation …
Tazarotene is a prodrug that belongs to the acetylenic class of retinoids. The drug was
subjected to hydrolytic, oxidative and photolytic stress testing to establish its comprehensive …
subjected to hydrolytic, oxidative and photolytic stress testing to establish its comprehensive …
Chromatographic separation of tiropramide hydrochloride and its degradation products along with their structural characterization using liquid chromatography …
M Tidke, VM Golla, BS Kushwah… - Biomedical …, 2023 - Wiley Online Library
Tiropramide HCl, a widely used antispasmodic drug, was subjected to various stress
conditions (hydrolytic, oxidative, photolytic and thermal) per International Council for …
conditions (hydrolytic, oxidative, photolytic and thermal) per International Council for …
LC-HRMS and NMR studies for the characterization of degradation impurities of ubrogepant along with the in silico approaches for the prediction of degradation and …
S Chaganti, U Chauhan, N Bhatt… - … of Pharmaceutical and …, 2024 - Elsevier
Ubrogepant is the first oral calcitonin gene-related peptide (CGRP) receptor antagonist
which is used for the acute treatment of migraine in adults. The present study employs liquid …
which is used for the acute treatment of migraine in adults. The present study employs liquid …
Isolation and identification of forced degradation products of Febuxostat
R Kanagaddi, V Chintala… - Separation …, 2024 - Wiley Online Library
The current study explains the degradation behavior of Febuxostat API, a non‐purine
xanthine oxidase inhibitor used to treat hyperuricemia. A degradation study was carried out …
xanthine oxidase inhibitor used to treat hyperuricemia. A degradation study was carried out …