Renal clearable catalytic gold nanoclusters for in vivo disease monitoring
Ultrasmall gold nanoclusters (AuNCs) have emerged as agile probes for in vivo imaging, as
they exhibit exceptional tumour accumulation and efficient renal clearance properties …
they exhibit exceptional tumour accumulation and efficient renal clearance properties …
Studying the fate of tumor extracellular vesicles at high spatiotemporal resolution using the zebrafish embryo
Tumor extracellular vesicles (EVs) mediate the communication between tumor and stromal
cells mostly to the benefit of tumor progression. Notably, tumor EVs travel in the …
cells mostly to the benefit of tumor progression. Notably, tumor EVs travel in the …
Membrane sculpting by curved DNA origami scaffolds
HG Franquelim, A Khmelinskaia, JP Sobczak… - Nature …, 2018 - nature.com
Membrane sculpting and transformation is essential for many cellular functions, thus being
largely regulated by self-assembling and self-organizing protein coats. Their functionality is …
largely regulated by self-assembling and self-organizing protein coats. Their functionality is …
Antigen discrimination by T cells relies on size-constrained microvillar contact
T cells use finger-like protrusions called 'microvilli'to interrogate their targets, but why they do
so is unknown. To form contacts, T cells must overcome the highly charged, barrier-like layer …
so is unknown. To form contacts, T cells must overcome the highly charged, barrier-like layer …
Photoswitchable gating of non-equilibrium enzymatic feedback in chemically communicating polymersome nanoreactors
The circadian rhythm generates out-of-equilibrium metabolite oscillations that are controlled
by feedback loops under light/dark cycles. Here we describe a non-equilibrium nanosystem …
by feedback loops under light/dark cycles. Here we describe a non-equilibrium nanosystem …
PAM: a framework for integrated analysis of imaging, single-molecule, and ensemble fluorescence data
Fluorescence microscopy and spectroscopy data hold a wealth of information on the
investigated molecules, structures, or organisms. Nowadays, the same fluorescence data set …
investigated molecules, structures, or organisms. Nowadays, the same fluorescence data set …
Temporal control of gene expression by the pioneer factor Zelda through transient interactions in hubs
J Dufourt, A Trullo, J Hunter, C Fernandez… - Nature …, 2018 - nature.com
Pioneer transcription factors can engage nucleosomal DNA, which leads to local chromatin
remodeling and to the establishment of transcriptional competence. However, the impact of …
remodeling and to the establishment of transcriptional competence. However, the impact of …
HIV-1 diverts cortical actin for particle assembly and release
Enveloped viruses assemble and bud from the host cell membranes. Any role of cortical
actin in these processes have often been a source of debate. Here, we assessed if cortical …
actin in these processes have often been a source of debate. Here, we assessed if cortical …
Measuring nanoscale diffusion dynamics in cellular membranes with super-resolution STED–FCS
Super-resolution microscopy techniques enable optical imaging in live cells with
unprecedented spatial resolution. They unfortunately lack the temporal resolution required …
unprecedented spatial resolution. They unfortunately lack the temporal resolution required …
The control of transcriptional memory by stable mitotic bookmarking
M Bellec, J Dufourt, G Hunt, H Lenden-Hasse… - Nature …, 2022 - nature.com
To maintain cellular identities during development, gene expression profiles must be
faithfully propagated through cell generations. The reestablishment of gene expression …
faithfully propagated through cell generations. The reestablishment of gene expression …