Renal clearable catalytic gold nanoclusters for in vivo disease monitoring

CN Loynachan, AP Soleimany, JS Dudani, Y Lin… - Nature …, 2019 - nature.com
Ultrasmall gold nanoclusters (AuNCs) have emerged as agile probes for in vivo imaging, as
they exhibit exceptional tumour accumulation and efficient renal clearance properties …

Studying the fate of tumor extracellular vesicles at high spatiotemporal resolution using the zebrafish embryo

V Hyenne, S Ghoroghi, M Collot, J Bons, G Follain… - Developmental cell, 2019 - cell.com
Tumor extracellular vesicles (EVs) mediate the communication between tumor and stromal
cells mostly to the benefit of tumor progression. Notably, tumor EVs travel in the …

Membrane sculpting by curved DNA origami scaffolds

HG Franquelim, A Khmelinskaia, JP Sobczak… - Nature …, 2018 - nature.com
Membrane sculpting and transformation is essential for many cellular functions, thus being
largely regulated by self-assembling and self-organizing protein coats. Their functionality is …

Antigen discrimination by T cells relies on size-constrained microvillar contact

E Jenkins, M Körbel, C O'Brien-Ball, J McColl… - Nature …, 2023 - nature.com
T cells use finger-like protrusions called 'microvilli'to interrogate their targets, but why they do
so is unknown. To form contacts, T cells must overcome the highly charged, barrier-like layer …

Photoswitchable gating of non-equilibrium enzymatic feedback in chemically communicating polymersome nanoreactors

O Rifaie-Graham, J Yeow, A Najer, R Wang, R Sun… - Nature Chemistry, 2023 - nature.com
The circadian rhythm generates out-of-equilibrium metabolite oscillations that are controlled
by feedback loops under light/dark cycles. Here we describe a non-equilibrium nanosystem …

PAM: a framework for integrated analysis of imaging, single-molecule, and ensemble fluorescence data

W Schrimpf, A Barth, J Hendrix, DC Lamb - Biophysical journal, 2018 - cell.com
Fluorescence microscopy and spectroscopy data hold a wealth of information on the
investigated molecules, structures, or organisms. Nowadays, the same fluorescence data set …

Temporal control of gene expression by the pioneer factor Zelda through transient interactions in hubs

J Dufourt, A Trullo, J Hunter, C Fernandez… - Nature …, 2018 - nature.com
Pioneer transcription factors can engage nucleosomal DNA, which leads to local chromatin
remodeling and to the establishment of transcriptional competence. However, the impact of …

HIV-1 diverts cortical actin for particle assembly and release

R Dibsy, E Bremaud, J Mak, C Favard… - Nature …, 2023 - nature.com
Enveloped viruses assemble and bud from the host cell membranes. Any role of cortical
actin in these processes have often been a source of debate. Here, we assessed if cortical …

Measuring nanoscale diffusion dynamics in cellular membranes with super-resolution STED–FCS

E Sezgin, F Schneider, S Galiani, I Urbančič… - Nature protocols, 2019 - nature.com
Super-resolution microscopy techniques enable optical imaging in live cells with
unprecedented spatial resolution. They unfortunately lack the temporal resolution required …

The control of transcriptional memory by stable mitotic bookmarking

M Bellec, J Dufourt, G Hunt, H Lenden-Hasse… - Nature …, 2022 - nature.com
To maintain cellular identities during development, gene expression profiles must be
faithfully propagated through cell generations. The reestablishment of gene expression …