Neurodegenerative diseases are common, incurable neurological disorders with high
prevalence, and lead to memory, movement, language, and intelligence impairments …

Central nervous system (CNS) diseases are among the most difficult to treat, mainly
because the vast majority of the drugs fail to cross the blood-brain barrier (BBB) or to reach …

Huntington's disease (HD) is an autosomal dominant genetic disorder caused by an
expansion of the CAG repeat in the first exon of Huntingtin's gene. The associated …

Diseases affecting the central nervous system (CNS) are among the most disabling and the
most difficult to cure due to the presence of the blood–brain barrier (BBB) which represents …

Neurodegeneration is the loss of neuronal capacity and structure over time which causes
neurodegenerative disorders like Alzheimer, amyotrophic lateral sclerosis, Parkinson, and …

Blood-brain barrier (BBB) serves as an essential interface between central nervous system
(CNS) and its periphery, allowing selective permeation of ions, gaseous molecules, and …

Huntington's disease (HD) is caused by expanded CAG repeats in the huntingtin gene (HTT)
resulting in expression of mutant HTT proteins (mHTT) with extended polyglutamine tracts …

Cholesterol is an important metabolite and membrane component and is enriched in the
brain owing to its role in neuronal maturation and function. In the adult brain, cholesterol is …

Huntington's disease (HD) is a neurological disorder characterized by a reduction in
medium-spiny neurons in the brain. Currently, there is no cure for HD and treatment relies …

A drawback in the development of treatments that can reach the retina is the presence of
barriers in the eye that restrain compounds from reaching the target. Intravitreal injections …