Combating mosquito-borne diseases using genetic control technologies
Mosquito-borne diseases, such as dengue and malaria, pose significant global health
burdens. Unfortunately, current control methods based on insecticides and environmental …
burdens. Unfortunately, current control methods based on insecticides and environmental …
Symbionts and gene drive: two strategies to combat vector-borne disease
Mosquitoes bring global health problems by transmitting parasites and viruses such as
malaria and dengue. Unfortunately, current insecticide-based control strategies are only …
malaria and dengue. Unfortunately, current insecticide-based control strategies are only …
CRISPR/Cas9-based split homing gene drive targeting doublesex for population suppression of the global fruit pest Drosophila suzukii
AK Yadav, C Butler, A Yamamoto… - Proceedings of the …, 2023 - National Acad Sciences
Genetic-based methods offer environmentally friendly species-specific approaches for
control of insect pests. One method, CRISPR homing gene drive that target genes essential …
control of insect pests. One method, CRISPR homing gene drive that target genes essential …
Regulating the expression of gene drives is key to increasing their invasive potential and the mitigation of resistance
Homing-based gene drives use a germline source of nuclease to copy themselves at
specific target sites in a genome and bias their inheritance. Such gene drives can be …
specific target sites in a genome and bias their inheritance. Such gene drives can be …
Closing the gap to effective gene drive in Aedes aegypti by exploiting germline regulatory elements
MAE Anderson, E Gonzalez, JXD Ang… - Nature …, 2023 - nature.com
CRISPR/Cas9-based homing gene drives have emerged as a potential new approach to
mosquito control. While attempts have been made to develop such systems in Aedes …
mosquito control. While attempts have been made to develop such systems in Aedes …
A CRISPR homing gene drive targeting a haplolethal gene removes resistance alleles and successfully spreads through a cage population
Engineered gene drives are being explored as a new strategy in the fight against vector-
borne diseases due to their potential for rapidly spreading genetic modifications through a …
borne diseases due to their potential for rapidly spreading genetic modifications through a …
A toxin-antidote CRISPR gene drive system for regional population modification
Engineered gene drives based on a homing mechanism could rapidly spread genetic
alterations through a population. However, such drives face a major obstacle in the form of …
alterations through a population. However, such drives face a major obstacle in the form of …
Anopheles homing suppression drive candidates exhibit unexpected performance differences in simulations with spatial structure
Recent experiments have produced several Anopheles gambiae homing gene drives that
disrupt female fertility genes, thereby eventually inducing population collapse. Such drives …
disrupt female fertility genes, thereby eventually inducing population collapse. Such drives …
Suppression gene drive in continuous space can result in unstable persistence of both drive and wild‐type alleles
Rapid evolutionary processes can produce drastically different outcomes when studied in
panmictic population models vs. spatial models. One such process is gene drive, which …
panmictic population models vs. spatial models. One such process is gene drive, which …
A transcomplementing gene drive provides a flexible platform for laboratory investigation and potential field deployment
CRISPR-based gene drives can spread through wild populations by biasing their own
transmission above the 50% value predicted by Mendelian inheritance. These technologies …
transmission above the 50% value predicted by Mendelian inheritance. These technologies …