Pumps for microfluidic cell culture

CK Byun, K Abi‐Samra, YK Cho, S Takayama - Electrophoresis, 2014 - Wiley Online Library
In comparison to traditional in vitro cell culture in Petri dishes or well plates, cell culture in
microfluidic‐based devices enables better control over chemical and physical environments …

A review on microfluidics manipulation of the extracellular chemical microenvironment and its emerging application to cell analysis

P Chen, S Li, Y Guo, X Zeng, BF Liu - Analytica Chimica Acta, 2020 - Elsevier
Spatiotemporal manipulation of extracellular chemical environments with simultaneous
monitoring of cellular responses plays an essential role in exploring fundamental biological …

VEGFR1 promotes cell migration and proliferation through PLCγ and PI3K pathways

JC Weddell, S Chen, PI Imoukhuede - NPJ systems biology and …, 2017 - nature.com
The ability to control vascular endothelial growth factor (VEGF) signaling offers promising
therapeutic potential for vascular diseases and cancer. Despite this promise, VEGF-targeted …

Temporal bias: time-encoded dynamic GPCR signaling

M Grundmann, E Kostenis - Trends in pharmacological sciences, 2017 - cell.com
Evidence suggests that cells can time-encode signals for secure transport and perception of
information, and it appears that this dynamic signaling is a common principle of nature to …

Logic digital fluidic in miniaturized functional devices: Perspective to the next generation of microfluidic lab‐on‐chips

Q Zhang, M Zhang, L Djeghlaf, J Bataille… - …, 2017 - Wiley Online Library
Microfluidics has emerged following the quest for scale reduction inherent to micro‐and
nanotechnologies. By definition, microfluidics manipulates fluids in small channels with …

A sharp-edge-based acoustofluidic chemical signal generator

PH Huang, CY Chan, P Li, Y Wang, N Nama… - Lab on a Chip, 2018 - pubs.rsc.org
Resolving the temporal dynamics of cell signaling pathways is essential for regulating
numerous downstream functions, from gene expression to cellular responses. Mapping …

Integrated perfusion and separation systems for entrainment of insulin secretion from islets of Langerhans

L Yi, X Wang, R Dhumpa, AM Schrell, N Mukhitov… - Lab on a Chip, 2015 - pubs.rsc.org
A microfluidic system was developed to investigate the entrainment of insulin secretion from
islets of Langerhans to oscillatory glucose levels. A gravity-driven perfusion system was …

Entrainment to periodic initiation and transition rates in a computational model for gene translation

M Margaliot, ED Sontag, T Tuller - PloS one, 2014 - journals.plos.org
Periodic oscillations play an important role in many biomedical systems. Proper functioning
of biological systems that respond to periodic signals requires the ability to synchronize with …

A Markovian approach to the optimal demodulation of diffusion-based molecular communication networks

CT Chou - IEEE Transactions on Communications, 2015 - ieeexplore.ieee.org
In a diffusion-based molecular communication network, transmitters and receivers
communicate by using signalling molecules (or ligands) in a fluid medium. This paper …

Silibinin (Milk Thistle) potentiates ethanol-dependent hepatocellular carcinoma progression in male mice

E Brandon-Warner, AL Eheim, DM Foureau, TL Walling… - Cancer letters, 2012 - Elsevier
Hepatocellular carcinoma (HCC) is a global health burden with limited treatment options
and poor prognosis. Silibinin, an antioxidant derived from the Milk Thistle plant (Silybum …