Psychiatric illnesses may be qualified to the cellular impairments of the function for survival
or death in neurons, which may consequently appear as abnormalities in the neuroplasticity …

Phosphoinositides, the seven phosphorylated derivatives of phosphatidylinositol have
emerged as regulators of key sub-cellular processes such as membrane transport …

INTRODUCTION White matter in the human brain serves a critical role in organizing
distributed neural networks. Diffusion magnetic resonance imaging (dMRI) has enabled the …

Background DNA methylation (DNAm) is a critical regulator of both development and
cellular identity and shows unique patterns in neurons. To better characterize maturational …

Methods integrating genetics with transcriptomic reference panels prioritize risk genes and
mechanisms at only a fraction of trait-associated genetic loci, due in part to an overreliance …

Abnormal neurotransmission is central to schizophrenia (SZ). Alterations across multiple
neurotransmitter systems in SZ suggest that this illness may be associated with …

Background The pathogenesis of schizophrenia is still unknown. Nearly a half of
schizophrenic patients have depressive symptoms and even some impulsive behaviors. The …

AKT is implicated in neurological disorders. AKT has three isoforms, AKT1/AKT2/AKT3, with
brain cell type-specific expression that may differentially influence behavior. Therefore, we …

Tetramethylpyrazine (TMP) has neuroprotective effects in the pathogenesis of some human
diseases, such as Parkinson's disease. The present study aimed to investigate the role of …

The serine/threonine protein kinase v-AKT homologs (AKTs), are implicated in typical and
atypical neurodevelopment. Akt isoforms Akt1, Akt2, and Akt3 have been extensively studied …