Blocking the anoxic depolarization protects without functional compromise following simulated stroke in cortical brain slices
TR Anderson, CR Jarvis… - Journal of …, 2005 - journals.physiology.org
Within 2 min of stroke onset, neurons and glia in brain regions most deprived of blood (the
ischemic core) undergo a sudden and profound loss of membrane potential caused by …
ischemic core) undergo a sudden and profound loss of membrane potential caused by …
σ1-Receptor Ligand 4-Phenyl-1-(4-Phenylbutyl)-Piperidine Affords Neuroprotection From Focal Ischemia With Prolonged Reperfusion
I Harukuni, A Bhardwaj, AB Shaivitz, AC DeVries… - Stroke, 2000 - Am Heart Assoc
Background and Purpose—We previously showed that the intravenous administration of the
potent ς1-receptor ligand 4-phenyl-1-(4-phenylbutyl)-piperidine (PPBP) provides …
potent ς1-receptor ligand 4-phenyl-1-(4-phenylbutyl)-piperidine (PPBP) provides …
Examining protection from anoxic depolarization by the drugs dibucaine and carbetapentane using whole cell recording from CA1 neurons
SH White, CD Brisson… - Journal of …, 2012 - journals.physiology.org
As an immediate consequence of stroke onset, failure of the Na+-K+-ATPase pump evokes
a propagating anoxic depolarization (AD) across gray matter. Acute neuronal swelling and …
a propagating anoxic depolarization (AD) across gray matter. Acute neuronal swelling and …
Does ischemia cause acute neuronal damage by converting the Na+/K+ pump into a channel?
D Kim - 2014 - library-archives.canada.ca
The gray matter of the higher brain undergoes spreading depolarization in response to
ischemia, which increases metabolic demand and so promotes acute neuronal injury. The …
ischemia, which increases metabolic demand and so promotes acute neuronal injury. The …