In July 2022, these guidelines were reviewed by an expert work group convened by ASH.
Review included limited searches for new evidence and discussion of the search results …

Blood transfusion is the most common procedure completed during a given hospitalization
in the United States. Although often life-saving, transfusions are not risk-free. One sequela …

Sickle cell disease is a common and life-threatening haematological disorder that affects
millions of people worldwide. Abnormal sickle-shaped erythrocytes disrupt blood flow in …

Red cell transfusion remains a critical component of care for acute and chronic
complications of sickle cell disease. Randomized clinical trials demonstrated the benefits of …

Genomics is affecting all areas of medicine. In transfusion medicine, DNA-based genotyping
is being used as an alternative to serological antibody-based methods to determine blood …

Over the past few decades, significant advances in the care of patients with sickle cell
disease (SCD) have led to improvements in morbidity and survival. The average life span of …

BACKGROUND Although red blood cell (RBC) transfusion represents an integral
component of sickle cell disease (SCD) care, transfusion support for some patients can …

Red blood cell (RBC) transfusion is a life-saving therapeutic tool. However, a major
complication in transfusion recipients is the generation of antibodies against non-ABO …

Sickle cell disease remains a major public health concern in sub-Saharan Africa, Europe,
and the United States. The survival rate of children and adolescents has increased …

Since the discovery of the ABO blood group in the early 20th century, more than 300 blood
group antigens have been categorized among 35 blood group systems. The molecular basis …