[HTML][HTML] Various biomimetics, including peptides as antifungals

E Efremenko, A Aslanli, N Stepanov, O Senko… - Biomimetics, 2023 - mdpi.com
Biomimetics, which are similar to natural compounds that play an important role in the
metabolism, manifestation of functional activity and reproduction of various fungi, have a …

[HTML][HTML] Cdc14 phosphatase contributes to cell wall integrity and pathogenesis in Candida albicans

KL Milholland, A AbdelKhalek, KM Baker… - Frontiers in …, 2023 - frontiersin.org
The Cdc14 phosphatase family is highly conserved in fungi. In Saccharomyces cerevisiae,
Cdc14 is essential for down-regulation of cyclin-dependent kinase activity at mitotic exit …

Development of Novel Phosphonodifluoromethyl-Containing Phosphotyrosine Mimetics and a First-In-Class, Potent, Selective, and Bioavailable Inhibitor of Human …

J Dong, BA Jassim, KL Milholland, Z Qu… - Journal of Medicinal …, 2024 - ACS Publications
Together with protein tyrosine kinases, protein tyrosine phosphatases (PTPs) control protein
tyrosine phosphorylation and regulate numerous cellular functions. Dysregulated PTP …

[HTML][HTML] The anti-fungal activity of nitropropenyl benzodioxole (NPBD), a redox-thiol oxidant and tyrosine phosphatase inhibitor

G Nicoletti, K White - Antibiotics, 2022 - mdpi.com
Phylogenetically diverse fungal species are an increasing cause of severe disease and
mortality. Identification of new targets and development of new fungicidal drugs are required …

[HTML][HTML] Membrane Protein Bcest Is Involved in Hyphal Growth, Virulence and Stress Tolerance of Botrytis cinerea

W Zhang, BB Ge, ZY Lv, KS Park, LM Shi, KC Zhang - Microorganisms, 2023 - mdpi.com
Botrytis cinerea is a necrotrophic model fungal plant pathogen that causes grey mould, a
devastating disease responsible for large losses in the agriculture sector. As important …

Reduced Cdc14 phosphatase activity impairs septation, hyphal differentiation and pathogenesis and causes echinocandin hypersensitivity in Candida albicans

KL Milholland, A AbdelKhalek, KM Baker, S Hoda… - bioRxiv, 2022 - biorxiv.org
The Cdc14 phosphatase family is highly conserved in fungi. In Saccharomyces cerevisiae,
Cdc14 is essential for down-regulation of cyclin-dependent kinase activity at mitotic exit …

Various Biomimetics as Antifungals

E Efremenko, A Aslanli, N Stepanov, O Senko… - 2023 - preprints.org
Biomimetics, which are similar to natural compounds that play an important role in the
metabolism, manifestation of functional activity and reproduction of various fungi, have a …

Phosphoproteomic strategies for protein functional characterization of phosphatases and kinases

AG DeMarco - 2024 - hammer.purdue.edu
Protein phosphorylation is a ubiquitous post-translational modification controlled by the
opposing activities of protein kinases and phosphatases, which regulate diverse biological …

CHARACTERIZATION OF CDC14 PHOSPHATASE BIOCHEMICAL MECHANISMS AND THEIR RELATIONSHIP TO FUNGAL PATHOGENESIS

KL Milholland - 2023 - hammer.purdue.edu
The Cdc14 phosphatase family is highly conserved in fungi. In Saccharomyces cerevisiae,
Cdc14 is essential for down-regulation of cyclin-dependent kinase activity at mitotic exit …

Form Cdc14 Phosphatase Contributes to Cell Wall Integrity and Pathogenesis in Candida Albicans

KL Milholland, A AbdelKhalek, KM Baker, S Hoda… - 2023 - docs.lib.purdue.edu
The Cdc14 phosphatase family is highly conserved in fungi. In Saccharomyces cerevisiae,
Cdc14 is essential for down-regulation of cyclin-dependent kinase activity at mitotic exit …