Selective vulnerability of specific brain regions and cell populations is a hallmark of
neurodegenerative disorders. Mechanisms of selective vulnerability involve neuronal …

As an essential component of our innate immune system, the complement system is
responsible for our defense against pathogens. The complement cascade has complex …

Importance For the Alzheimer disease (AD) therapies to effectively attenuate clinical
progression, it may be critical to intervene before the onset of amyloid-associated tau …

Background Dementia is a prevalent non-motor manifestation among individuals with
advanced Parkinson's disease (PD). Glial fibrillary acidic protein (GFAP) is an inflammatory …

Reactive astrocytes play an important role in the development of Alzheimer's disease (AD).
Here, we aimed to investigate the temporospatial relationships among monoamine oxidase …

Recent successive approval of anti-amyloid-β (Aβ) monoclonal antibodies as disease-
modifying therapies against Alzheimer's disease (AD) has raised great confidence in the …

The risk of developing Alzheimer's disease (AD) significantly increases in individuals
carrying the APOEε4 allele. Elderly cognitively healthy individuals with APOEε4 also exist …

INTRODUCTION We studied how biomarkers of reactive astrogliosis mediate the
pathogenic cascade in the earliest Alzheimer's disease (AD) stages. METHODS We …

Gut dysbiosis and psychiatric symptoms are common early manifestations of Alzheimer's
disease (AD) and Parkinson's disease (PD). These diseases, characterised by progressive …

Brain imaging techniques using PET improve our understanding of the different AD-related
pathologies and their relationship with each other along the course of disease. With more …