In addition to their role in binding antigen, antibodies can regulate immune responses
through interacting with Fc receptors (FcRs). In recent years, significant progress has been …

Since the description of the first mouse knockout for an IgG Fc receptor seven years ago,
considerable progress has been made in defining the in vivo functions of these receptors in …

Immunoglobulin G (IgG) Fc receptors play a critical role in linking IgG antibody-mediated
immune responses with cellular effector functions. A high resolution map of the binding site …

The immune response depends on the binding of opsonized antigens to cellular Fc
receptors and the subsequent initiation of various cellular effector functions of the immune …

Allergic individuals exposed to minute quantities of allergen experience an immediate
response. Immediate hypersensitivity reflects the permanent sensitization of mucosal mast …

The direct or indirect targeting of antibody Fc receptors (FcRs) presents unique opportunities
and interesting challenges for the treatment of inflammatory diseases, cancer and infection …

Immunoglobulins couple the recognition of invading pathogens with the triggering of potent
effector mechanisms for pathogen elimination. Different immunoglobulin classes trigger …

Preclinical tests of therapeutic antibodies are frequently carried out in mice to evaluate
pharmacokinetics and efficacy. However, the observation that mouse IgG are cleared rapidly …

2004-11-10 Assigned to XENCOR, INC. reassignment XENCOR, INC. ASSIGNMENT OF
ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: DANG, WEI …

Multiple functions have recently been identified for the neonatal Fc receptor FcRn. In
addition, a human homolog of the rodent forms of FcRn has been identified and …