Insights into the development of 99mTc-radioligands for serotonergic receptors imaging: Synthesis, labeling, In vitro, and In vivo studies
Abstract Serotonergic (5-hydroxytryptamine; 5-HT) receptors play critical roles in
neurological and psychological disorders such as schizophrenia, anxiety, depression, and …
neurological and psychological disorders such as schizophrenia, anxiety, depression, and …
Design, development and bio-evaluation of a novel radio-ligand 99mTc-THQ-DTPA as a sigma 2 receptor specific breast tumor imaging agent
V Chaudhary, S Chaturvedi, A Wadhwa… - Bioorganic & Medicinal …, 2024 - Elsevier
Over-expression of sigma-2 receptor in cancer cells provides an opportunity to develop
molecular probes for diagnosis, even for non-receptor specific malignancies like triple …
molecular probes for diagnosis, even for non-receptor specific malignancies like triple …
Synthesis and Biological Evaluation of 99mTc-Labeled Phenylpiperazine Derivatives as Selective Serotonin-7 Receptor Ligands for Brain Tumor Imaging
With a poor prognosis, glioblastoma multiforme is the most aggressive tumor of the central
nervous system in humans. The aim of this study was to develop novel tracers for the tumor …
nervous system in humans. The aim of this study was to develop novel tracers for the tumor …
Acetylated Benzothiazolone as Homobivalent SPECT Metallo-Radiopharmaceutical 99mTc-(6-AcBTZ) 2DTPA: Design, Synthesis, and Preclinical Evaluation for …
Mapping different structural forms of serotonin subtypes 5-HT1A–5-HT7 using a selective-
specific ligand with good pharmacokinetics and brain permeability can open avenues for …
specific ligand with good pharmacokinetics and brain permeability can open avenues for …