MicroRNAs as therapeutic targets in cardiovascular disease

B Laggerbauer, S Engelhardt - The Journal of clinical …, 2022 - Am Soc Clin Investig
The discovery of microRNAs and their role in diseases was a breakthrough that inspired
research into microRNAs as drug targets. Cardiovascular diseases are an area in which …

Non-canonical features of microRNAs: paradigms emerging from cardiovascular disease

D Santovito, C Weber - Nature Reviews Cardiology, 2022 - nature.com
Research showing that microRNAs (miRNAs) are versatile regulators of gene expression
has instigated tremendous interest in cardiovascular research. The overwhelming majority of …

Targeting a cell-specific microRNA repressor of CXCR4 ameliorates atherosclerosis in mice

I Cimen, L Natarelli, Z Abedi Kichi… - Science translational …, 2023 - science.org
The CXC chemokine receptor 4 (CXCR4) in endothelial cells (ECs) and vascular smooth
muscle cells (VSMCs) is crucial for vascular integrity. The atheroprotective functions of …

Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation

N Reglero-Real, L Pérez-Gutiérrez, A Yoshimura… - Immunity, 2021 - cell.com
The migration of neutrophils from the blood circulation to sites of infection or injury is a key
immune response and requires the breaching of endothelial cells (ECs) that line the inner …

Autophagy, pyroptosis, and ferroptosis: new regulatory mechanisms for atherosclerosis

L Lin, MX Zhang, L Zhang, D Zhang, C Li… - Frontiers in cell and …, 2022 - frontiersin.org
Atherosclerosis is a chronic inflammatory disorder characterized by the gradual buildup of
plaques within the vessel wall of middle-sized and large arteries. The occurrence and …

Autophagy at the interface of endothelial cell homeostasis and vascular disease

E Mameli, A Martello, A Caporali - The FEBS journal, 2022 - Wiley Online Library
Autophagy is an essential intracellular process for cellular quality control. It enables cell
homeostasis through the selective degradation of harmful protein aggregates and damaged …

Emerging functional principles of tRNA-derived small RNAs and other regulatory small RNAs

Q Chen, T Zhou - Journal of Biological Chemistry, 2023 - ASBMB
Recent advancements in small RNA sequencing have unveiled a previously hidden world of
regulatory small noncoding RNAs (sncRNAs) that extend beyond the well-studied small …

Immunoinflammatory, thrombohaemostatic, and cardiovascular mechanisms in COVID-19

S Gencer, M Lacy, D Atzler… - Thrombosis and …, 2020 - thieme-connect.com
The global coronavirus disease 2019 (COVID-19) pandemic has deranged the recent
history of humankind, afflicting more than 27 million individuals to date. While the majority of …

Circulating extracellular vesicle microRNAs associated with adverse reactions, proinflammatory cytokine, and antibody production after COVID-19 vaccination

Y Miyashita, T Yoshida, Y Takagi, H Tsukamoto… - npj Vaccines, 2022 - nature.com
Abstract mRNA-based vaccines have been used globally to eradicate the coronavirus-
disease 2019 (COVID-19) pandemic. Vaccine efficacy and adverse reactions depend on …

Exploring the role of non-coding RNAs in autophagy

S Ghafouri-Fard, H Shoorei, M Mohaqiq, J Majidpoor… - Autophagy, 2022 - Taylor & Francis
As a self-degradative mechanism, macroautophagy/autophagy has a role in the
maintenance of energy homeostasis during critical periods in the development of cells. It …