Active DNA demethylation promotes cell fate specification and the DNA damage response
Neurons harbor high levels of single-strand DNA breaks (SSBs) that are targeted to
neuronal enhancers, but the source of this endogenous damage remains unclear. Using two …
neuronal enhancers, but the source of this endogenous damage remains unclear. Using two …
[HTML][HTML] 'Men are but worms:'neuronal cell death in C. elegans and vertebrates
GV Putcha, EM Johnson - Cell Death & Differentiation, 2004 - nature.com
Abstract Awarding the 2002 Nobel Prize in Physiology or Medicine to Sydney Brenner, H
Robert Horvitz, and John E Sulston for 'their discoveries concerning the genetic regulation of …
Robert Horvitz, and John E Sulston for 'their discoveries concerning the genetic regulation of …
Base-modified nucleosides as chemotherapeutic agents: past and future
MP Burke, KM Borland… - Current Topics in Medicinal …, 2016 - ingentaconnect.com
Nucleoside and nucleobase antimetabolites have substantially impacted treatment of cancer
and infections. Their close resemblance to natural analogs gives them the power to interfere …
and infections. Their close resemblance to natural analogs gives them the power to interfere …
No evidence for new dopaminergic neurons in the adult mammalian substantia nigra
H Frielingsdorf, K Schwarz… - Proceedings of the …, 2004 - National Acad Sciences
A recent report by Zhao et al.[Zhao, M., Momma, S., Delfani, K., Carlen, M., Cassidy, RM,
Johansson, CB, Brismar, H., Shupliakov, O., Frisen, J. & Janson, AM (2003) Proc. Natl. Acad …
Johansson, CB, Brismar, H., Shupliakov, O., Frisen, J. & Janson, AM (2003) Proc. Natl. Acad …
Bax, Bcl2, and p53 differentially regulate neomycin-and gentamicin-induced hair cell death in the zebrafish lateral line
Sensorineural hearing loss is a normal consequence of aging and results from a variety of
extrinsic challenges such as excessive noise exposure and certain therapeutic drugs …
extrinsic challenges such as excessive noise exposure and certain therapeutic drugs …
Bcl-xL is essential for the survival and function of differentiated neurons in the cortex that control complex behaviors
A Nakamura, V Swahari, C Plestant, I Smith… - Journal of …, 2016 - Soc Neuroscience
Apoptosis plays an essential role during brain development, yet the precise mechanism by
which this pathway is regulated in the brain remains unknown. In particular, mammalian …
which this pathway is regulated in the brain remains unknown. In particular, mammalian …
[HTML][HTML] 6-OHDA generated ROS induces DNA damage and p53-and PUMA-dependent cell death
AI Bernstein, SP Garrison, GP Zambetti… - Molecular …, 2011 - Springer
Background Parkinson's disease (PD) is characterized by the selective loss of dopaminergic
neurons in the substantia nigra (SN), resulting in tremor, rigidity, and bradykinesia. Although …
neurons in the substantia nigra (SN), resulting in tremor, rigidity, and bradykinesia. Although …
[HTML][HTML] Allosteric potentiation of GABAA receptor single-channel conductance by netrin-1 during neuronal-excitation-induced inhibitory synaptic homeostasis
As the principal receptor that mediates both synaptic and tonic inhibition of neurons in the
brain, the A-type gamma-aminobutyric acid receptor (GABA AR) is functionally important for …
brain, the A-type gamma-aminobutyric acid receptor (GABA AR) is functionally important for …
[HTML][HTML] Ribosomal Protein S3, a New Substrate of Akt, Serves as a Signal Mediator between Neuronal Apoptosis and DNA Repair [S]
RPS3, a conserved, eukaryotic ribosomal protein of the 40 S subunit, is required for
ribosome biogenesis. Because ribosomal proteins are abundant and ubiquitous, they may …
ribosome biogenesis. Because ribosomal proteins are abundant and ubiquitous, they may …
The BH3‐only protein Puma is both necessary and sufficient for neuronal apoptosis induced by DNA damage in sympathetic neurons
A Wyttenbach, AM Tolkovsky - Journal of neurochemistry, 2006 - Wiley Online Library
DNA damage activates apoptosis in several neuronal populations and is an important
component of neuropathological conditions. While it is well established that neuronal …
component of neuropathological conditions. While it is well established that neuronal …