The burden of cancer is increasing globally. Several challenges facing its mainstream
treatment approaches have formed the basis for the development of targeted delivery …

Immunotoxins (ITs) are attractive anticancer modalities aimed at cancer-specific delivery of
highly potent cytotoxic protein toxins. An IT consists of a targeting domain (an antibody …

Eukaryotic life depends upon the interplay between vast networks of signaling pathways
composed of upwards of 109–1010 proteins per cell. The integrity and normal operation of …

Cancer immunotherapy aims to selectively target and kill tumor cells whilst limiting the
damage to healthy tissues. Controlled delivery of plant, bacterial and human toxins or …

The epidermal growth factor receptor (EGFR) has been recognized as an important
therapeutic target in oncology. It is commonly overexpressed in a variety of solid tumors and …

Targeted cancer therapy includes, amongst others, antibody-based delivery of toxic
payloads to selectively eliminate tumor cells. This payload can be either a synthetic small …

Patient-specific targeted therapy represents the holy grail of anti-cancer therapeutics,
allowing potent tumor depletion without detrimental off-target toxicities. Disease-specific …

While biomedical investigation has greatly advanced, investigators have lost touch with and
inadvertently corrupted significant nomenclature at the foundation of their science …

Aureins, natural active peptides extracted from skin secretions of Australian bell frogs, have
become a research focus due to the antitumor effects caused by lysing cell membranes …

Eukaryotic life depends upon the interplay between vast networks of signaling pathways
composed of upwards of 109-1010 proteins per cell. The integrity and normal operation of …