The eukaryotic cell is a bustling collection of macromolecules acting cooperatively to
mediate the functions required for cell viability. Specific, context-dependent and tightly …

Many human diseases are the result of abnormal protein–protein interactions involving
endogenous proteins, proteins from pathogens or both. The inhibition of these aberrant …

Peptide-protein interactions are very prevalent, mediating key processes such as signal
transduction and protein trafficking. How can peptides overcome the entropic cost involved …

Background: Over the last two decades, an increasing research effort in academia and
industry has focused on the modulation (both inhibition and stabilization) of protein–protein …

The receptor for advanced glycation endproducts (RAGE) binds diverse ligands linked to
chronic inflammation and disease. NMR spectroscopy and x-ray crystallization studies of the …

Severe acute respiratory syndrome virus 2 (SARS-CoV-2) belongs to the single-stranded
positive-sense RNA family. The virus contains a large genome that encodes four structural …

Protein–protein interactions play key roles in a range of biological processes, and are
therefore important targets for the design of novel therapeutics. Unlike in the design of …

Due to their key roles in a number of biological processes, protein–protein interactions are
attractive and important targets, typically involving areas greater than 6nm2. The disruption …

Using a biologically relevant peptide or protein structure as a starting point for lead
identification represents one of the most powerful approaches in modern drug discovery …

Identifying the interface between two interacting proteins provides important clues to the
function of a protein, and is becoming increasing relevant to drug discovery. Here, surface …