β2 Integrins—multi-functional leukocyte receptors in health and disease
M Bednarczyk, H Stege, S Grabbe, M Bros - International journal of …, 2020 - mdpi.com
β2 integrins are heterodimeric surface receptors composed of a variable α (CD11a-CD11d)
and a constant β (CD18) subunit and are specifically expressed by leukocytes. The α …
and a constant β (CD18) subunit and are specifically expressed by leukocytes. The α …
Structural basis of kindlin-mediated integrin recognition and activation
Kindlins and talins are integrin-binding proteins that are critically involved in integrin
activation, an essential process for many fundamental cellular activities including cell-matrix …
activation, an essential process for many fundamental cellular activities including cell-matrix …
[HTML][HTML] Long-term management of leukocyte adhesion deficiency type III without hematopoietic stem cell transplantation
P Saultier, S Szepetowski, M Canault, C Falaise… - …, 2018 - ncbi.nlm.nih.gov
Leukocyte adhesion deficiency type III (LAD-III) is a recessive autosomal condition
characterized by bleeding events and life-threatening infections. This condition is due to …
characterized by bleeding events and life-threatening infections. This condition is due to …
Hematologically important mutations: leukocyte adhesion deficiency (second update)
D Roos, K Van Leeuwen, M Madkaikar… - Blood Cells, Molecules …, 2023 - Elsevier
Leukocyte adhesion deficiency (LAD) is an immunodeficiency caused by defects in the
adhesion of leukocytes (especially neutrophils) to the blood vessel wall. As a result, patients …
adhesion of leukocytes (especially neutrophils) to the blood vessel wall. As a result, patients …
Quantitative proteome analysis of brain subregions and spinal cord from experimental autoimmune encephalomyelitis mice by TMT‐based mass spectrometry
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS); its
cause is unknown. To understand the pathogenesis of MS, researchers often use the …
cause is unknown. To understand the pathogenesis of MS, researchers often use the …
[HTML][HTML] Prognostic implications of novel gene signatures in gastric cancer microenvironment
M Sun, J Qiu, H Zhai, Y Wang, P Ma, M Li… - … medical journal of …, 2020 - ncbi.nlm.nih.gov
Background Increasing studies have shown the important clinical role of immune and
stromal cells in gastric cancer microenvironment. Based on information of immune and …
stromal cells in gastric cancer microenvironment. Based on information of immune and …
Comparative analysis of histologically classified oligodendrogliomas reveals characteristic molecular differences between subgroups
Background Molecular data of histologically classified oligodendrogliomas are available
offering the possibility to stratify these human brain tumors into clinically relevant molecular …
offering the possibility to stratify these human brain tumors into clinically relevant molecular …
Precision medicine in Thailand
V Shotelersuk, S Tongsima… - American Journal of …, 2019 - Wiley Online Library
Extraordinary advances in high throughput next generation sequencing (NGS) technology
and bioinformatics are the main thrust that transforms the current state of healthcare into the …
and bioinformatics are the main thrust that transforms the current state of healthcare into the …
Successful hematopoietic stem cell transplant in leukocyte adhesion deficiency type III presenting primarily as malignant infantile osteopetrosis
MF Essa, E Elbashir, F Alroqi, R Mohammed… - Clinical …, 2020 - Elsevier
Leukocyte adhesion deficiency type III (LAD-III) is caused by mutations in FERMT3 that
encodes Kindlin-3 which regulates integrins activation. LAD-III predisposes to infections and …
encodes Kindlin-3 which regulates integrins activation. LAD-III predisposes to infections and …
Case report: a case of leukocyte adhesion deficiency, type III presenting with impaired platelet function, lymphocytosis and Granulocytosis
AM Yahya, AA AlMulla, HJ AlRufaye… - Frontiers in …, 2021 - frontiersin.org
Fermitin family homolog 3 (FERMT3), alternatively kindlin-3 (KIND3), is an integrin binding
protein (of 667 residues) encoded by the FERMT3 gene. The molecule is essential for …
protein (of 667 residues) encoded by the FERMT3 gene. The molecule is essential for …