β2 integrins are heterodimeric surface receptors composed of a variable α (CD11a-CD11d)
and a constant β (CD18) subunit and are specifically expressed by leukocytes. The α …

Kindlins and talins are integrin-binding proteins that are critically involved in integrin
activation, an essential process for many fundamental cellular activities including cell-matrix …

Leukocyte adhesion deficiency type III (LAD-III) is a recessive autosomal condition
characterized by bleeding events and life-threatening infections. This condition is due to …

Leukocyte adhesion deficiency (LAD) is an immunodeficiency caused by defects in the
adhesion of leukocytes (especially neutrophils) to the blood vessel wall. As a result, patients …

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS); its
cause is unknown. To understand the pathogenesis of MS, researchers often use the …

Background Increasing studies have shown the important clinical role of immune and
stromal cells in gastric cancer microenvironment. Based on information of immune and …

Background Molecular data of histologically classified oligodendrogliomas are available
offering the possibility to stratify these human brain tumors into clinically relevant molecular …

Extraordinary advances in high throughput next generation sequencing (NGS) technology
and bioinformatics are the main thrust that transforms the current state of healthcare into the …

Leukocyte adhesion deficiency type III (LAD-III) is caused by mutations in FERMT3 that
encodes Kindlin-3 which regulates integrins activation. LAD-III predisposes to infections and …

Fermitin family homolog 3 (FERMT3), alternatively kindlin-3 (KIND3), is an integrin binding
protein (of 667 residues) encoded by the FERMT3 gene. The molecule is essential for …