[HTML][HTML] The physiological, biochemical, and molecular roles of zinc transporters in zinc homeostasis and metabolism

T Kambe, T Tsuji, A Hashimoto… - Physiological …, 2015 - journals.physiology.org
Zinc is involved in a variety of biological processes, as a structural, catalytic, and intracellular
and intercellular signaling component. Thus zinc homeostasis is tightly controlled at the …

Zinc and its role in immunity and inflammation

P Bonaventura, G Benedetti, F Albarède… - Autoimmunity reviews, 2015 - Elsevier
Zinc (Zn) nutritional importance has been known for a long time, but in the last decades its
importance in immune modulation has arisen. This review aims at describing the …

[HTML][HTML] The essential toxin: impact of zinc on human health

LM Plum, L Rink, H Haase - … journal of environmental research and public …, 2010 - mdpi.com
Compared to several other metal ions with similar chemical properties, zinc is relatively
harmless. Only exposure to high doses has toxic effects, making acute zinc intoxication a …

[HTML][HTML] Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis

A Weiss, CC Murdoch, KA Edmonds, MR Jordan… - Cell, 2022 - cell.com
Zinc (Zn) is an essential micronutrient and cofactor for up to 10% of proteins in living
organisms. During Zn limitation, specialized enzymes called metallochaperones are …

[HTML][HTML] Mechanistic impact of zinc deficiency in human development

A Hussain, W Jiang, X Wang, S Shahid, N Saba… - Frontiers in …, 2022 - frontiersin.org
Zinc (Zn) deficiency in humans is an emerging global health issue affecting approximately
two billion people across the globe. The situation prevails due to the intake of Zn deficient …

Current understanding of ZIP and ZnT zinc transporters in human health and diseases

T Kambe, A Hashimoto, S Fujimoto - Cellular and molecular life sciences, 2014 - Springer
Abstract Zinc transporters, the Zrt-, Irt-like protein (ZIP) family and the Zn transporter (ZnT)
family transporters, are found in all aspects of life. Increasing evidence has clarified the …

Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes–associated variants

TJ Nicolson, EA Bellomo, N Wijesekara, MK Loder… - Diabetes, 2009 - Am Diabetes Assoc
OBJECTIVE Zinc ions are essential for the formation of hexameric insulin and hormone
crystallization. A nonsynonymous single nucleotide polymorphism rs13266634 in the …

[HTML][HTML] Zinc Deficiency Induces Membrane Barrier Damage and Increases Neutrophil Transmigration in Caco-2 Cells1

A Finamore, M Massimi, LC Devirgiliis… - The Journal of nutrition, 2008 - Elsevier
Zinc may contribute to the host defense by maintaining the membrane barrier. In this study,
we questioned whether zinc deficiency affects the membrane function and junctional …

[HTML][HTML] Trace elements in glucometabolic disorders: an update

N Wiernsperger, JR Rapin - Diabetology & metabolic syndrome, 2010 - Springer
Many trace elements, among which metals, are indispensable for proper functioning of a
myriad of biochemical reactions, more particularly as enzyme cofactors. This is particularly …

[HTML][HTML] Zinc transporters and dysregulated channels in cancers

Z Pan, S Choi, H Ouadid-Ahidouch… - Frontiers in …, 2017 - ncbi.nlm.nih.gov
As a nutritionally essential metal ion, zinc (Zn) not only constitutes a structural element for
more than 3000 proteins but also plays important regulatory functions in cellular signal …