Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …

The transcription factor NF-κB is a central mediator of inflammation with multiple links to
thrombotic processes. In this review, we focus on the role of NF-κB signaling in cell types …

Hodgkin's lymphoma was first described in 1832. The aetiology of this lymphoma, however,
remained enigmatic for a long time. Only within the past 10 years has the B-cell nature of the …

The roles of the JAK/STAT, Raf/MEK/ERK and PI3K/Akt signal transduction pathways and
the BCR-ABL oncoprotein in leukemogenesis and their importance in the regulation of cell …

Nuclear factor (NF)-κB is a family of seven structurally related transcription factors that play a
central role in cardiovascular growth, stress response, and inflammation by controlling gene …

Proliferation and survival of Hodgkin and Reed/Sternberg (HRS) cells, the malignant cells of
classical Hodgkin lymphoma (cHL), are dependent on constitutive activation of nuclear …

Dendritic cells (DCs) are potent antigen-presenting cells with a pivotal role in antigen-
specific immune responses. Here, we found that the helix-loop-helix transcription factor Id2 …

The CCR7 chemokine axis is comprised of chemokine ligand 21 (CCL21) and chemokine
ligand 19 (CCL19) acting on chemokine receptor 7 (CCR7). This axis plays two important …

The Activator Protein-1 (AP-1) transcription factor (TF) family, composed of a variety of
members including c-JUN, c-FOS and ATF, is involved in mediating many biological …

Upon TCR engagement, naive CD4 T cells differentiate toward the Th1 or Th2 phenotype. IL-
4, acting through Stat6, plays a major role in Th2 differentiation; IL-2 has also been reported …