The ability to sense physical forces is conserved across all organisms. Cells convert
mechanical stimuli into electrical or chemical signals via mechanically activated ion …

Physical forces are ubiquitous in biological processes across scales and diverse contexts.
This review highlights the significance of mechanical forces in nervous system development …

Macrophages perform diverse functions within tissues during immune responses to
pathogens and injury, but molecular mechanisms by which physical properties of the tissue …

Osteoarthritis (OA) is a painful and debilitating condition of synovial joints without any
disease-modifying therapies [AM Valdes, TD Spector, Nat. Rev. Rheumatol. 7, 23–32 …

The evolutionarily conserved Piezo channel family, including Piezo1 and Piezo2 in
mammals, serves as versatile mechanotransducers in various cell types and consequently …

The term 'fibroblast'often serves as a catch-all for a diverse array of mesenchymal cells,
including perivascular cells, stromal progenitor cells and bona fide fibroblasts. Although …

The fluid-mosaic model posits a liquid-like plasma membrane, which can flow in response to
tension gradients. It is widely assumed that membrane flow transmits local changes in …

Membrane tension is thought to be a long-range integrator of cell physiology. Membrane
tension has been proposed to enable cell polarity during migration through front-back …

Activation of mechanosensitive ion channels underlies a variety of fundamental
physiological processes that require sensation of mechanical force. Different …

The mechanically activated Piezo channel plays a versatile role in conferring
mechanosensitivity to various cell types. However, how it incorporates its intrinsic …