The phosphoenolpyruvate (PEP): carbohydrate phosphotransferase system (PTS) is found
only in bacteria, where it catalyzes the transport and phosphorylation of numerous …

Understanding the function of biological macromolecules and their complexes at the
physicochemical level requires knowledge of both their structure and dynamics …

Kinetic data on a number of protein–protein associations have provided evidence for the
initial formation of a pre-equilibrium encounter complex that subsequently relaxes to the final …

NMR spectroscopy is a key method for studying the structure and dynamics of (large)
multidomain proteins and complexes in solution. It plays a unique role in integrated …

Imposing a very slight deviation from the isotropic random distribution of macromolecules in
solution in an NMR sample tube permits the measurement of residual internuclear dipolar …

The function of bio-macromolecules is determined by both their 3D structure and
conformational dynamics. These molecules are inherently flexible systems displaying a …

Weak protein–protein interactions (PPIs) are fundamental to many cellular processes, such
as reversible cell–cell contact, rapid enzyme turnover and transient assembly and/or …

Mannose transporters constitute a superfamily (Man-PTS) of the Phosphoenolpyruvate
Carbohydrate Phosphotransferase System (PTS). The membrane complexes are …

Escherichia coli can uptake and utilize many common natural sugars to form biomass or
valuable target bio-products. Carbon catabolite repression (CCR) will occur and hamper the …

Recent technological advances in NMR spectroscopy have alleviated the size limitations for
the determination of biomolecular structures in solution. At the same time, novel NMR …