Applying a social determinants of health framework, this review brings attention to evidence
from social sciences and neuroscience on the role of selected social factors in individual …

Until recently, most modern neuroscience research on addiction using animal models did
not incorporate manipulations of social factors. Social factors play a critical role in human …

While social context has long been considered central to substance use disorder prevention
and treatment and many drug-taking events occur in social settings, experimental research …

Neuro-ethological studies conducted by Panksepp and his colleagues have provided an
understanding of how the activity of the mesolimbic dopaminergic (ML DA) system leads to …

Drug addiction is one of the leading causes of mortality worldwide. Despite great advances
were achieved in understanding the neurobiology of drug addiction, the therapeutic options …

Rationale Given that many patients being treated for opioid-use disorder continue to use
drugs, identifying clusters of patients who share similar patterns of use might provide insight …

Many personality traits are influenced by genetic factors. Rodents models provide an
efficient system for analyzing genetic contribution to these traits. Using 1,246 adolescent …

Humans have used opioids to suppress moderate to severe pain for thousands of years.
However, the long-term use of opioids has several adverse effects, such as opioid tolerance …

Ketamine is a dissociative anesthetic first developed in the 1960s but is increasingly used at
subanesthetic doses for both clinical and non-clinical purposes. There is evidence from …

Drug abuse is a worldwide problem that leads to negative physical, mental, and economic
consequences. Although pharmacological strategies for drug addiction management have …