Endotoxin tolerance and trained immunity: breaking down immunological memory barriers
E López-Collazo, C Del Fresno - Frontiers in Immunology, 2024 - frontiersin.org
For decades, innate immune cells were considered unsophisticated first responders, lacking
the adaptive memory of their T and B cell counterparts. However, mounting evidence …
the adaptive memory of their T and B cell counterparts. However, mounting evidence …
Oral immunization with heat-inactivated Mycobacterium bovis reduces local parasite dissemination and hepatic granuloma development in mice infected with …
Aiming to explore whether oral immunization with heat-inactivated Mycobacterium bovis
(HIMB) protects mice against Leishmania infection, 18 female BALB/c mice were randomly …
(HIMB) protects mice against Leishmania infection, 18 female BALB/c mice were randomly …
Heat-killed Mycobacterium tuberculosis induces trained immunity in vitro and in vivo administered systemically or intranasally
L Minute, M Bergón-Gutiérrez, P Mata-Martínez… - Iscience, 2024 - cell.com
Trained immunity (TI) represents a memory-like process of innate immune cells. TI can be
initiated with various compounds such as fungal β-glucan or the tuberculosis vaccine …
initiated with various compounds such as fungal β-glucan or the tuberculosis vaccine …
Candida albicans infection model in Drosophila melanogaster suggests a strain-specific virulent factor boosting a stormy innate immune response
M Cortacans, M Arch, E Fuentes… - Frontiers in …, 2024 - frontiersin.org
Intorduction Pathogens drive the evolution of host defence strategies, with both innate and
adaptive immune systems playing key roles. Priming enhances the innate immune system's …
adaptive immune systems playing key roles. Priming enhances the innate immune system's …
Mycobacterium tuberculosis Antigen Rv1471 Induces Innate Immune Memory and Adaptive Immunity against Infection
X Huang, J Wu, J Xu, H Wang, Z Chen… - The Journal of …, 2024 - academic.oup.com
Protein subunit vaccines form a key pipeline for developing novel tuberculosis (TB)
vaccines. Mycobacterium tuberculosis (Mtb) contains approximately 4000 individual …
vaccines. Mycobacterium tuberculosis (Mtb) contains approximately 4000 individual …
Establishment of an in vitro model of monocyte-like THP-1 cells for trained immunity induced by bacillus Calmette-Guérin
JC Xu, K Wu, R Ma, J Li, J Tao, Z Hu, XY Fan - BMC microbiology, 2024 - Springer
Background Mycobacteria bloodstream infections are common in immunocompromised
people and usually have disastrous consequences. As the primary phagocytes in the …
people and usually have disastrous consequences. As the primary phagocytes in the …