Forward genetic screens are powerful tools for the discovery and functional annotation of
genetic elements. Recently, the RNA-guided CRISPR (clustered regularly interspaced short …

Image-based screening is used to measure a variety of phenotypes in cells and whole
organisms. Combined with perturbations such as RNA interference, small molecules, and …

Forward genetic screens are powerful tools for the unbiased discovery and functional
characterization of specific genetic elements associated with a phenotype of interest …

During mitosis, adherent animal cells undergo a drastic shape change, from essentially flat
to round,,. Mitotic cell rounding is thought to facilitate organization within the mitotic cell and …

EBImage provides general purpose functionality for reading, writing, processing and
analysis of images. Furthermore, in the context of microscopy-based cellular assays …

BH3-only proteins integrate apoptosis and autophagy pathways, yet regulation and
functional consequences of pathway cross-talk are not fully resolved. The BH3-only protein …

Despite our rapidly growing knowledge about the human genome, we do not know all of the
genes required for some of the most basic functions of life. To start to fill this gap we …

Clathrin-mediated endocytosis (CME) is the major pathway of epidermal growth factor
receptor (EGFR) internalization. It is commonly believed that CME mediates long-term …

Mass spectrometry in high-throughput proteomics: ready for the big time | Nature Methods Skip
to main content Thank you for visiting nature.com. You are using a browser version with limited …

Background Image-based screens can produce hundreds of measured features for each of
hundreds of millions of individual cells in a single experiment. Results Here, we describe …